Publications by authors named "Lawrence Zhao"
Article Synopsis
- Endocannabinoids are natural molecules that interact with cannabinoid receptors to regulate various bodily functions, sparking interest in drugs targeting these receptors.
- Current research has not fully explained how endocannabinoids selectively bind to different cannabinoid receptor subtypes, with recent studies suggesting a role of the receptor's N-terminus and its lipid access channel.
- Two hypotheses are proposed for the selectivity of the endocannabinoid anandamide: one related to the specific interactions during binding due to N-terminus movement, and the other concerning the differences in binding pocket volume affecting ligand conformational entropy, supported by extensive molecular dynamics simulations.
