Publications by authors named "Lawrence Tucker"
Article Synopsis
- Hypochlorous acid (HOCl) is important for fighting pathogens, but too much or too little can cause tissue damage and inflammation.
- The new HOClSense dyes use a chlorination-based mechanism to provide detailed visualization of HOCl levels in sub-cellular environments, offering both switch-on and switch-off detection with different emission colors.
- Researchers demonstrated HOClSense's effectiveness by mapping HOCl in cell structures like plasma membranes and lysosomes, revealing insights into HOCl production in diseases like Niemann-Pick.
Introduction: To examine electroencephalogram (EEG) as a diagnostic tool for late-onset efavirenz (EFV) neurotoxicity syndrome (LENS), an uncommon but severe and potentially fatal complication of EFV therapy.
Methods: We conducted a Retrospective case-control study. EEGs from confirmed cases of LENS (clinical syndrome and plasma EFV >4ug/mL) recorded from June 2016 to May 2021 were compared with control EEGs from the same time-period.
Background: Epilepsy is a common neurological disorder, associated with serious cognitive, physical, and psychosocial burdens. Mesial temporal lobe epilepsy (mTLE) is the commonest form of focal epilepsy. The aim of this study was to establish the incidence of patients with electroencephalographic epileptiform discharges consistent with mTLE attending a tertiary hospital in South Africa, and determine whether these patients may be candidates for anterior temporal lobectomy.
View Article and Find Full Text PDFObjective: To determine the effectiveness of a 6-month, interactive, multimodal, Web-based EEG teaching program (EEG) in improving EEG analysis and interpretation skills for neurologists, neurology residents, and technologists, particularly in resource-limited settings.
Methods: Between June 2017 and November 2018, 179 learners originating from 20 African countries, Europe, and the United States were registered on the EEG course. Of these, 128 learners (91% African) participated in the study.
Introduction: Growing evidence of the teratogenic potential of sodium valproate (VPA) has changed prescribing practices across the globe; however, the impact of this research and the consequent dissemination of a Dear Health Care Professional Letter (DHCPL) in December 2015, recommending avoidance of the teratogen VPA in women of childbearing age (WOCBA) and pregnant women in South Africa, is unknown. We explored trends and reasons for VPA use among pregnant women and WOCBA in the public sector in Western Cape Province from 1 January 2015 to 31 December 2017.
Methods: Using the provincial health information exchange that collates routine electronic health data via unique patient identifiers, we analysed clinical and pharmacy records from 2015 to 2017 to determine prescription patterns of VPA and other antiepileptic drug (AED) and mood-stabilising medicine (MSM) use in WOCBA and pregnant women.