Publications by authors named "Lawrence Pinsky"

Space radiation is a notable hazard for long-duration human spaceflight. Associated risks include cancer, cataracts, degenerative diseases and tissue reactions from large, acute exposures. Space radiation originates from diverse sources, including galactic cosmic rays, trapped-particle (Van Allen) belts and solar-particle events.

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We detect regular particle showers in several compact pixel detectors, distributed over the International Space Station. These showers are caused by high energy galactic cosmic rays, with energies often in the 10 s of TeV or higher. We survey the frequency of these events, their dependence on location on ISS, and their independence of the location of ISS, on its orbit.

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Article Synopsis
  • Early assessment of neoadjuvant systemic therapy (NAST) response is important for triple-negative breast cancer (TNBC) patients to prevent harmful side effects from ineffective treatments.
  • The study evaluated functional tumor volumes (FTVs) using dynamic contrast-enhanced (DCE) MRI after the 2nd and 4th cycles of NAST in 100 patients, finding FTVs at these points could indicate treatment response.
  • Results showed that 49% of patients achieved a pathologic complete response (pCR), with FTV at the 4th cycle having the best predictive accuracy (AUC = 0.84), while baseline FTV did not distinguish between pCR and non-pCR.
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Progress in the development of high-performance semiconductor radiation imaging pixel detectors based on technologies developed for use in high-energy physics applications has enabled the development of a completely new generation of compact low-power active dosimeters and area monitors for use in space radiation environments. Such detectors can provide real-time information concerning radiation exposure, along with detailed analysis of the individual particles incident on the active medium. Recent results from the deployment of detectors based on the Timepix from the CERN-based Medipix2 Collaboration on the International Space Station (ISS) are reviewed, along with a glimpse of developments to come.

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