Publications by authors named "Lawrence Mills"
Article Synopsis
- The study focused on the use of plasma transfusions in 85 anaesthetized dogs, analyzing when and why plasma was administered, along with monitoring for adverse events and human errors during transfusion processes.
- The primary reasons for plasma transfusion included sepsis (58% of dogs) and perianaesthetic hypotension, particularly with 39% of dogs experiencing hypotension as the sole trigger for the transfusion.
- Despite a common practice of bolusing plasma rather than following recommended slow rates, no transfusion reactions were clearly identified, indicating potential masking effects due to anaesthesia in critically ill dogs.
Background: Reindeer are becoming popular animals within petting farms. Few case reports describe the sedation of domesticated reindeer, but none describe the use of ocular local anesthetic blocks in this species.
Case Description: A 9-year-old, female, Svalbard reindeer ( ) presenting for removal of a squamous cell carcinoma involving the third eyelid.
The endothelial glycocalyx (eGlx) is a critically important structure lining the luminal surface of endothelial cells. There is increasing evidence, in human patients and animal models, for its crucial role in the maintenance of health. Moreover, its damage is associated with the pathogenesis of multiple disease states.
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- The endothelial glycocalyx (eGlx) is a vital layer on endothelial cells that helps maintain vascular health, and its damage is linked to various diseases.
- This study used established techniques to visualize the eGlx in the microvasculature of reproductive tissues in five healthy dogs during elective neutering, focusing on uterine and testicular arteries.
- The results showed that eGlx was successfully visualized in the arteries of two dogs, revealing specific depths, but highlighted the need for further research to improve methods for measuring eGlx health in clinical settings.
The endothelial glycocalyx (eGlx) lines the luminal surface of endothelial cells, maintaining vascular health. Glycocalyx damage is pathophysiologically important in many diseases across species however few studies have investigated its breakdown in naturally occurring disease in dogs. The aims of the study were to investigate eGlx damage in dogs with myxomatous mitral valve disease (MMVD) diagnosed on echocardiography, and dogs in a hypercoagulable state diagnosed using thromboelastography (TEG), by measuring serum hyaluronan concentrations.
View Article and Find Full Text PDFPemphigus vulgaris (PV) is an autoimmune blistering disorder of the skin and mucosal surfaces characterized by acantholysis (loss of adhesion between epidermal cells). Esophageal involvement of PV is an underdiagnosed entity as routine diagnostic endoscopy is not recommended in asymptomatic patients. Dysphagia and odynophagia are common presenting symptoms; however, upper gastrointestinal bleeding (UGIB) associated with esophageal involvement of PV without a history of mucosal blistering is extremely uncommon.
View Article and Find Full Text PDFGastric Mucormycosis: An Infection of Fungal Invasion into the Gastric Mucosa in Immunocompromised Patients.
Case Rep Gastrointest Med
September 2020
Primary gastric mucormycosis is a rare but potentially lethal fungal infection due to the invasion of Mucorales into the gastric mucosa. It may result in high mortality due to increased risk of complications in immunocompromised patients. Common predisposing risk factors to develop gastric mucormycosis are prolonged uncontrolled diabetes mellitus with or without diabetic ketoacidosis (DKA), solid organ or stem cell transplantation, underlying hematologic malignancy, and major trauma.
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