Publications by authors named "Lawrence Jenkins"

Article Synopsis
  • - The study aimed to evaluate whether testosterone therapy (TTh) affects the rates of biochemical recurrence (BCR) in men with low-intermediate prostate cancer who have undergone radical prostatectomy (RP).
  • - A total of 5,199 men were studied, with 198 receiving TTh post-RP; the analysis adjusted for factors like age and preoperative PSA levels.
  • - Results showed a slightly lower risk of BCR in men on TTh, but overall BCR rates were low in both groups, suggesting TTh can be safe for select men after RP without increasing BCR risk.
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Objective: To quantify the risk of long-term post-radical prostatectomy (RP) erectile dysfunction (ED) in men with diabetes mellitus (DM).

Methods: We included men who underwent RP and were followed for ≥24 months at our institution; men were excluded if they received androgen deprivation therapy or radiation therapy. Erectile function recovery (EFR) was assessed using the International Index of Erectile Function (IIEF) Erectile Function Domain (EFD) score pre-RP and serially during follow-up.

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Article Synopsis
  • - The study aimed to identify factors influencing the length of penile implants in men undergoing primary inflatable penile prosthesis (IPP) placement at multiple surgical centers from July 2016 to July 2021.
  • - Findings revealed that older age, Asian ethnicity, history of radical prostatectomy, and the infrapubic surgical approach were linked to shorter implant lengths, while Black or African American ethnicity was associated with longer implants.
  • - Understanding these associations can help doctors better counsel patients about potential implant lengths and set realistic expectations for postoperative outcomes.
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Introduction: The prevalence of male sexual dysfunction (MSD) increases with age, with >50% of men aged >40 years reporting erectile dysfunction (ED). In recent years, wearable male sex devices (WMSDs) have been increasingly utilized by patients and recommended by sexual medicine clinicians.

Objectives: This study seeks to investigate the safety and efficacy of products currently marketed for the treatment of MSD.

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Introduction: The associated symptoms of hypogonadism have been reported in patients with various types of cancer. However, the prevalence and significance of hypogonadism among certain hematologic malignancies have not been completely summarized in recent literature.

Objective: In this review we aimed to examine the current literature on hypogonadism in patients with hematologic malignancies, with emphasis on leukemias, lymphomas, and multiple myeloma (MM).

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Article Synopsis
  • A study was conducted to investigate how climate variations influence the risk of infections in patients receiving inflatable penile prosthesis (IPP) surgery across multiple international medical centers.
  • The research analyzed data from 5,289 patients, finding no statistically significant correlation between the season or month of surgery, daily temperature, humidity, or dew point, and the occurrence of infections, which were relatively low at 1.9%.
  • The results suggest that urologists don't need to adjust infection prevention strategies based on climate conditions when performing IPP surgeries.
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Purpose: The purpose of this white paper is to educate health care professionals about the evolution of telemedicine (TM) and to propose a hybrid model that leverages the strengths of traditional in-person medicine as well as virtual medicine while maximizing the safety and quality of men's sexual health care.

Literature Search Strategy: A literature search focused on the use of TM in urology and men's health was performed through PubMed/MEDLINE, Embase, and Web of Science (January 1, 2012-April 26, 2022). Keywords included all known permutations of the terminology used to refer to virtual health, care as well as the terminology used to refer to urologic diseases, issues specific to men's health, and men's sexual health concerns.

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Purpose: There have been conflicting studies on the association between phosphodiesterase type 5 inhibitor (PDE5i) use and biochemical recurrence (BCR) following radical prostatectomy (RP). Our aim was to determine whether PDE5i drug exposure after RP increases the risk of BCR in patients undergoing RP.

Materials And Methods: An institutional database of prostate cancer patients treated between January 2009 and December 2020 was reviewed.

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Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system and is widely recognized as a disease primarily affecting women. The relationship between MS and hypogonadism is complex and not fully understood, with recent evidence showing that hypogonadism may have a significant impact on the quality of life and disease progression of patients with MS.

Objectives: This review aims to provide an overview of the current knowledge regarding the relationship between MS and hypogonadism, including the mechanisms underlying this relationship; the effects of hypogonadism on patients with MS; and the potential benefits and drawbacks of testosterone replacement therapy for patients with MS and hypogonadism.

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Background: Phosphodiesterase type 5 (PDE5) inhibitor labeling states that these agents should not be used in conjunction with other erectogenic medications for fear of priapism occurring.

Aim: We explored the risk of priapism and prolonged erections in men in our post-radical prostatectomy (RP) penile injection program who were using regular PDE5 inhibitor and intracavernosal injections (ICIs) as part of their rehabilitation program.

Methods: The study cohort included men on penile injection therapy who (1) were taking tadalafil 5 mg daily or taking sildenafil 25 mg on noninjection days, (2) had an RP, (3) were using their respective PDE5 inhibitor regularly at the time of penile injection training, and (4) complied with the program instructions regarding penile injection use.

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Inflatable Penile Prostheses (IPP) implantation is a surgical treatment for patients desiring definitive treatment for erectile dysfunction. While this procedure has proven to be effective, it also carries its own set of unique risks that need to be carefully considered. The article reviews the current understanding of complications associated with penile prosthetic surgery and provides strategies to mitigate these adverse events.

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A penile prosthesis/implant is an excellent option for men with erectile dysfunction refractory to medical treatment or with contraindications to medical management. In this narrative review, we discuss the different types of penile prostheses and the considerations for patient and device selection to maximize satisfaction. There are three main prosthesis types to choose from: three-piece inflatable devices, two-piece inflatable devices, and malleable/semirigid devices.

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Background: In 2017, a prospective multicenter, multinational, investigational pilot study was conducted examining outcomes using a novel surgical technique, the Mini-Jupette sling, for the management of erectile dysfunction (ED) patients with climacturia and/or minimal stress urinary incontinence (SUI) after prostate procedures. Climacturia has been reported in up to 64% of patients following radical prostatectomy (RP). We sought to report the 5-year outcomes from this original cohort to assess long-term safety and effectivity of the mini-jupette sling in the treatment of ED and concomitant mild SUI and/or climacturia.

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Background: Corporal fibrosis is known to result from prolonged priapism; however, the impact of the timing of penile prosthesis placement after priapism on complication rates is poorly understood.

Aim: We sought to evaluate the impact of timing of inflatable penile prosthesis (IPP) placement on complications in men with a history of ischemic priapism.

Methods: We performed a multicenter, retrospective cohort study of patients with a history of priapism undergoing IPP placement by 10 experienced implantation surgeons.

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Background: Telemedicine gained wide acceptance during the COVID-19 pandemic, as it was deemed critical for patient care when lockdowns were implemented worldwide. While there is evidence to suggest that urology patients were receptive to telemedicine, no systematic review has been done to date on andrology patients and their perception of telemedicine.

Methods: Three electronic databases, PubMed, Scopus, and Web of Science, were searched from their inception until June 2022 for relevant articles.

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Objective: To develop and evaluate a mobile phone-based skills assessment tool that measures procedural competency of urology residents learning to perform a common, non-robotic urology procedure as a means of tracking current skillset and improvement over time.

Methods: The assessment tool was a Qualtrics survey accessed via a smartphone link that breaks down a vasectomy into 6 critical steps. Level of competency was measured on a scale of '1-novice' to '5-expert.

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Objective: To describe the infectious and non-infectious complications in men undergoing Inflatable penile prosthesis (IPP) revision with partial and complete component exchange for mechanical malfunction.

Methods: We performed a multicenter retrospective cohort study of patients who underwent IPP revision. Men undergoing procedures for implant infection were excluded.

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Introduction: Penile curvature is the most common abnormality that is observed by men with Peyronie's disease (PD). Collagenase Clostridium histolyticum (CCH) has become a standard treatment for PD patients.

Aim: To identify predictor factors associated with improvements of penile curvature outcomes in men with PD treated with CCH.

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After a focused telehealth visit, patients can now access phosphodiesterase-5 inhibitor (PDE5 inhibitor) prescriptions through online direct-to-consumer (DTC) healthcare companies. This study seeks to quantify the cost of DTC PDE5 inhibitor treatment compared to a traditional physician visit and local pharmacy prescription. Two DTC companies, two compounding pharmacies with national reach, three online Canadian pharmacies, and sixteen American pharmacy chains were queried for prices of 90-day regimens of common PDE5 inhibitors.

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Background: Despite physicians frequently caring for patients with sexual health issues, only 50% of United States medical schools require formal education in sexual medicine, and there are currently no guidelines pertaining to this with research which found that medical trainees are ill-equipped to provide sexual healthcare.

Aim: This study aims to identify areas to improve sexual health training in order to increase physician confidence and competence in evaluating and training patients with sexual health problems.

Methods: A prospective survey was sent via REDCap to medical students (n = 190, 68.

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Article Synopsis
  • There is currently no validated English-language patient-reported outcome (PRO) tool to measure satisfaction among men who receive inflatable penile prostheses (IPP), relying instead on surgeon assessments and unsuitable questionnaires.
  • The study aimed to create a validated PRO specifically designed to assess patient satisfaction post-IPP surgery by reviewing literature, consulting experts, and gathering patient feedback.
  • After refining the initial 35-item questionnaire through cognitive interviews and statistical analysis, researchers developed a final 16-item Satisfaction Survey for Inflatable Penile Implant (SSIPI), demonstrating high reliability and validity in measuring patient satisfaction levels.
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Introduction: Penile pain is one of the most stressful symptoms in men with Peyronie's disease (PD).

Aim: To evaluate the prevalence, clinical presentation and risk factors associated with penile pain in men with PD as well as to assess the psychosocial impact.

Methods: We revised our institution's database of men diagnosed with PD.

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Background: Intralesional collagenase such as Xiaflex (ILX) has become a standard treatment for Peyronie's disease (PD). Many robust studies have demonstrated its clear efficacy in the treatment algorithm.

Aim: To examine predictors of the patient decision to pursue ILX in PD patients.

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Background: Peyronie's disease (PD) has negative impacts on the psychosocial status of men including depression warranting clinical evaluation in up to 50% of men.

Aim: To examine predictors of depression in patients with early PD seeking evaluation.

Methods: All PD patients at a high-volume PD practice underwent screening and curvature assessment after intracavernosal injection.

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