Publications by authors named "Lawrence Gibson"
Background: National cancer reporting-based registry data, although robust, lacks granularity for incidence trends. Expert opinion remains conflicted regarding the possibility of melanoma overdiagnosis in the context of rising incidence without a corresponding rise in mortality.
Objective: To characterize 10- and 50-year trends in melanoma incidence and mortality.
Objective: To determine whether patients with lymphedema of a lower extremity (LE) had a greater risk of skin cancer than those without lymphedema.
Patients And Methods: This retrospective cohort study included patients with LE lymphedema examined at Mayo Clinic in Rochester, MN, USA, from January 1, 2000, through December 31, 2020. All patients with the phrase "lower extremity lymphedema" and a diagnostic code for lymphedema present in their electronic health record, as well as their age-, race-, and sex-matched controls without lymphedema, were included in the study.
Background And Objective: Primary cutaneous melanoma incidence is increasing in elderly individuals. This population-based cohort examines incidence and mortality rates among adults aged 61 years and older with cutaneous melanoma.
Materials And Methods: Using the Rochester Epidemiology Project, patients aged 61 years of age or older with a first lifetime diagnosis of cutaneous melanoma between January 1, 1970 and December 31, 2020 were identified.
Objective: To identify changes in the incidence and mortality of cutaneous melanoma in the fastest-growing segment of the US population, middle-aged adults.
Patients And Methods: Using the Rochester Epidemiology Project, patients aged 40 to 60 years with a first lifetime diagnosis of cutaneous melanoma between January 1, 1970, and December 31, 2020, while a resident of Olmsted County, Minnesota, were identified.
Results: A total of 858 patients with a primary cutaneous first-time melanoma were identified.
Article Synopsis
- Follicular mucinosis (FM) is a rare skin condition involving mucin buildup, often seen in children, with debates about its causes and potential for becoming malignant.
- A study investigated the long-term health outcomes of 14 pediatric patients diagnosed with FM, collecting data on their diagnosis, treatments, and health status.
- The results showed that none of the patients developed mycosis fungoides or other blood cancers, suggesting that FM in children is typically benign.
Article Synopsis
- * The patient experienced improvement in her infection symptoms, but then developed a severe skin rash characterized by bullous lesions, leading to further medical evaluation which confirmed the diagnosis.
- * The report emphasizes the need for awareness of skin conditions in dialysis patients, the significance of accurate diagnosis through biopsy, and the effectiveness of timely treatment, as evidenced by the patient's recovery after starting prednisone.
Background: Patients with hypertrophic lichen planus (HLP) and squamous cell carcinoma (SCC) diagnoses present clinicians with diagnostic and disease management challenges.
Objective: To better define the clinical and treatment outcomes of patients with concomitant diagnoses of HLP and SCC.
Methods And Materials: A retrospective review was performed from January 1, 2008, to July 31, 2015, at Mayo Clinic.
Autoimmune bullous dermatoses are characterized by the presence of tissue-bound and often circulating pathogenic autoantibodies targeting structural components of the skin and/or mucous membranes. The diagnostic workup for this heterogeneous group of disorders consists of a multi-step process, of which the light microscopic examination is a crucial component. This review is organized following a classification scheme that is based on two main histopathologic features, namely level of intraepithelial split and composition of the inflammatory infiltrate.
View Article and Find Full Text PDFAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) comprises a group of small vessel vasculitides grouped by commonalities of clinical manifestations and ANCA testing. Skin findings are not uncommon, although there is considerable overlap and many times nonspecificity. In general, patients with skin findings tend to have more significant systemic illness, and skin lesions most often develop simultaneously or following onset of systemic symptoms.
View Article and Find Full Text PDFBackground: ANCA-associated vasculitis (AAV) may present a wide array of dermatological manifestations. Patients may remain ANCA negative, rendering diagnosis challenging for dermatologists if they depend heavily on ANCA testing to either confirm or rule out AAV.
Objective: To compare clinical and histopathological features of AAV patients with skin lesions who are ANCA positive versus those who are ANCA negative.
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) can be associated with various cutaneous manifestations. Several case reports have described skin ulceration resembling pyoderma gangrenosum (PG), particularly in granulomatosis with polyangiitis (GPA); however, the true incidence of this PG-like ulceration in various diseases is unknown. In addition, PG is frequently misdiagnosed, and diagnosis may rely on exclusion of other causes of ulcers.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates if specific histopathological features in skin biopsies can predict systemic associations in patients with dermatomyositis (DM).
- It finds that while vacuolar interface dermatitis was the most common feature, no specific biopsy result reliably indicated other serious conditions like myopathy or interstitial lung disease.
- However, a correlation was noted between dense lichenoid infiltrate and severe itching, and MDA-5 antibody positive patients showed a higher likelihood of vasculopathy.
Background: Certain autoimmune bullous dermatoses are mediated by autoantibodies of the IgG4 subclass. We determined the diagnostic impact of adding IgG4 to our conventional direct immunofluorescence (DIF) panel.
Methods: For all cases submitted to our referral laboratory for DIF over 1 month (n = 630), we performed IgG4 testing and collected consecutive biopsy specimens showing definite or indeterminate linear or cell-surface deposition of IgG, IgG4, and/or C3.
Background: Intravascular histiocytosis is an underrecognized reactive skin condition characterized by the clinical finding of poorly demarcated erythematous to violaceous patches and plaques. The diagnosis is confirmed by the histologic findings of intraluminal histiocytes on skin biopsy and exclusion of an alternative diagnosis.
Methods: A review of patients with a histologic diagnosis of intravascular or intralymphatic histiocytosis and seen at Mayo Clinic, Rochester, Minnesota, from January 1, 2010, to October 10, 2020, was performed.
Background: The purpose of this study was to retrospectively assess clinical characteristics and mortality rate of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients who developed disseminated intravascular coagulation (DIC).
Methods: A systematic retrospective chart review of all patients with concurrent clinical diagnosis of DIC and SJS/TEN between July 1, 2012, and January 1, 2020, at the Mayo Clinic was performed.
Results: The incidence of DIC in patients with SJS/TEN was 1.
Granulomatous dermatoses may represent primary skin inflammation or can serve as the harbinger of a multitude of underlying systemic disorders or drug reactions. Taken together with clinical findings, the microscopic features from skin biopsy can allow recognition of various patterns and facilitate a precise diagnosis. Accurate classification of entities in this category of inflammatory dermatoses may prompt clinicians to investigate for underlying systemic problems, thereby allowing the pathologist to add considerable value in the care of affected patients.
View Article and Find Full Text PDFBackground: Focal or total skin radiation therapy can be used to treat mild to refractory cutaneous T-cell lymphoma.
Objective: To report the broad therapeutic benefit of radiation therapy for cutaneous T-cell lymphoma.
Methods: Retrospective, single-institution review of outcomes for skin-directed radiation therapy.