Cross-disorder and disease-specific pathways in dementia revealed by single-cell genomics.

The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNA-seq and ATAC-seq in Alzheimer's disease (AD), frontotemporal dementia (FTD), and progressive supranuclear palsy (PSP), analyzing 41 participants and ∼1 million cells (RNA + ATAC) from three brain regions varying in vulnerability and pathological burden. We identify 32 shared, disease-associated cell types and 14 that are disease specific.

Genetic Risk For Depression and Quality of Life in Patients With Head and Neck Cancer.

Importance: Although patients with head and neck cancer (HNC) have been shown to experience high distress, few longitudinal studies include a comprehensive evaluation of biopsychosocial factors affecting quality of life (QoL), including genetic risk for depression.

Objective: To identify factors at the time of cancer diagnosis associated with QoL scores at 3 months after treatment in patients newly diagnosed with a first occurrence of HNC.

Design, Setting, And Participants: This prospective longitudinal study of 1464 participants with a 3-month follow-up, including structured clinical interviews and self-administered measures was carried out at the Department of Otolaryngology Head and Neck Surgery at 2 tertiary care McGill University Affiliated Hospitals, McGill University Health Centre, and Jewish General Hospital.

IRS-assisted vehicular visible light communications systems: channel modeling and performance analysis.

Visible light communications (VLC) is a promising solution as an alternative for the fully occupied radio frequency bands in the near future. The rear (tail) and front of vehicles have lamps that can be used for vehicular visible light communications (VVLC) systems. However, one of the main challenges of VLC systems is the line-of-sight (LoS) blockage issue.

Independent Prediction of Child Psychiatric Symptoms by Maternal Mental Health and Child Polygenic Risk Scores.

Objective: Prenatal maternal symptoms of depression and anxiety are associated with an increased risk for child socioemotional and behavioral difficulties, supporting the fetal origins of mental health hypothesis. However, to date, studies have not considered specific genomic risk as a possible confound.

Method: The Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (n = 5,546) was used to test if child polygenic risk score for attention-deficit/hyperactivity disorder (ADHD), schizophrenia, or depression confounds or modifies the impact of prenatal maternal depression and anxiety on child internalizing, externalizing, and total emotional/behavioral symptoms from age 4 to 16 years.

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics.

The development of successful therapeutics for dementias requires an understanding of their shared and distinct molecular features in the human brain. We performed single-nuclear RNAseq and ATACseq in Alzheimer disease (AD), Frontotemporal degeneration (FTD), and Progressive Supranuclear Palsy (PSP), analyzing 40 participants, yielding over 1.4M cells from three brain regions ranging in vulnerability and pathological burden.

AL-aided AMC in a multi-user white-light OFDMA VLC system over a light-diffusing fiber loop.

To develop an adaptive modulation scheme for flexible high-speed multi-user visible light communication (VLC), automatic modulation classification (AMC) is adopted for monitoring the modulation formats of different subcarrier groups. An AMC scheme based on a joint convolutional neural network (CNN), active learning (AL), and data augmentation (DA) is demonstrated over an orthogonal frequency division multiplexing access (OFDMA) VLC system. The configuration of the diffuse white-light VLC system is combined with a pair integrated transceiver module, a light-diffusing fiber (LDF), and a wireless channel, which can provide white-light illumination and ubiquitous access.

EZH2 Methyltransferase Regulates Neuroinflammation and Neuropathic Pain.

Recent studies by us and others have shown that enhancer of zeste homolog-2 (EZH2), a histone methyltransferase, in glial cells regulates the genesis of neuropathic pain by modulating the production of proinflammatory cytokines and chemokines. In this review, we summarize recent advances in this research area. EZH2 is a subunit of polycomb repressive complex 2 (PRC2), which primarily serves as a histone methyltransferase to catalyze methylation of histone 3 on lysine 27 (H3K27), ultimately resulting in transcriptional repression.

Polarization independent Bragg gratings using tilted subwavelength grating waveguide Bragg gratings.

We propose and experimentally demonstrate a polarization independent subwavelength grating (SWG) waveguide Bragg grating (WBG) by using an SWG waveguide with tilted segments. By optimizing the tilting angle and other geometry parameters, such as the width and the length of the loading segments used to create the BG, we can obtain a zero birefringence tilted SWG waveguide and consequently, a polarization independent SWG WBG. In our simulations, the optimal tilting angle is ∼ 58°, whereas the optimal angle obtained in fabrication is ∼ 46°.

Electrically reconfigurable waveguide Bragg grating filters.

We propose and demonstrate an electrically reconfigurable waveguide Bragg grating filters in silicon-on-insulator using a multiple-contact heater element. There are six electrical pads connected to the heater element in an equidistant manner. These electrical pads allow to create different heat, and corresponding refractive index, distributions across the grating so that the local Bragg wavelength corresponding to the heated segments can be controlled.

Reconfigurable microwave photonic filter based on a quantum dash mode-locked laser.

We demonstrate a reconfigurable microwave photonic (MWP) filter using a quantum dash (QDash) mode-locked laser (MLL) that can generate an optical frequency comb (OFC) with ∼50 comb lines and a free spectral range of 25 GHz. Thanks to the large number of comb lines, the MWP filter responses can be easily programmed by tailoring the OFC spectrum. We implement MWP filter responses with Gaussian, sinc, flat-top, and multiple peaks, as well as demonstrate that tuning of the central frequency.

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites.

Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well understood. The PUFA, docosahexaenoic acid (DHA), inhibits agonist responses of the pLGIC, ELIC, more effectively than palmitic acid, similar to the effects observed in the GABA receptor and nicotinic acetylcholine receptor. Using photo-affinity labeling and coarse-grained molecular dynamics simulations, we identified two fatty acid binding sites in the outer transmembrane domain (TMD) of ELIC.

Bacterial Quorum Sensing Signals Promote Large-Scale Remodeling of Lipid Membranes.

We report that -acyl-l-homoserine lactones (AHLs), a class of nonionic amphiphiles that common bacteria use as signals to coordinate group behaviors, can promote large-scale remodeling in model lipid membranes. Characterization of supported lipid bilayers (SLBs) of the phospholipid 1,2-dioleoyl--glycero-3-phosphocholine (DOPC) by fluorescence microscopy and quartz crystal microbalance with dissipation (QCM-D) reveals the well-studied AHL signal 3-oxo-C12-AHL and its anionic head group hydrolysis product (3-oxo-C12-HS) to promote the formation of long microtubules that can retract into hemispherical caps on the surface of the bilayer. These transformations are dynamic, reversible, and dependent upon the head group structure.

Dual-frequency optoelectronic oscillator incorporating a single cavity and multiband microwave photonic filter.

Dual-frequency optoelectronic oscillators (OEOs) have potential applications in dual-band wireless networking and dual-parameter sensing systems. We propose a dual-frequency OEO incorporating a multiband microwave photonic filter (MPF). In particular, the two microwave signals are generated simultaneously in a single OEO cavity.

Polarization-dependent tuning of Bragg reflection enabled through tilted subwavelength grating waveguide Bragg gratings.

We propose and demonstrate experimentally tilted subwavelength grating (SWG) waveguide Bragg gratings (WBGs). By tilting the SWG segments and optimizing the duty cycle, we can achieve polarization-dependent tuning of the spectral response of the SWG WBG, namely, the spectral response of the fundamental transverse electric (TE) mode shifts toward shorter wavelengths, while that for the transverse magnetic (TM) mode remains almost unchanged. In particular, for tilting angles of 5° and 30°, we can obtain a blueshift in the Bragg wavelength of 7 and 35 nm for the TE mode, while the Bragg wavelength for the TM mode remains within 0.