Using patient preference to inform ritlecitinib dose selection for alopecia areata treatment.

Ritlecitinib is an oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma (JAK3/TEC) family kinase inhibitor approved for the treatment of severe alopecia areata (AA). Benefit-risk profiles of two doses of ritlecitinib (50 mg vs 30 mg once daily) were evaluated by integrating patient preferences and clinical efficacy and safety estimates for ritlecitinib. A discrete-choice experiment (DCE) was utilized to elicit preferences for benefit and safety attributes of systemic AA treatments.

"When I talk about it, my eyes light up!" Impacts of a national laboratory internship on community college student success.

Participation in technical/research internships may improve undergraduate graduation rates and persistence in science, technology, engineering, and mathematics (STEM), yet little is known about the benefits of these activities a) for community college students, b) when hosted by national laboratories, and c) beyond the first few years after the internship. We applied Social Cognitive Career Theory (SCCT) to investigate alumni perspectives about how CCI at Lawrence Berkeley National Laboratory (LBNL) impacted their academic/career activities. We learned that alumni had low confidence and expectations of success in STEM as community college students.

Performance evaluation of a Cadre Forensics TopMatch-GS 3D system for cartridge case comparisons.

Three-dimensional (3D) measurement systems for firearm forensics are becoming more prevalent in forensic laboratories, and these instruments are typically coupled with algorithms to assist firearm examiners with comparisons. Due to differences in firearm feature reproducibility on different types of ammunition, comparison algorithms need to be tested utilizing a variety of ammunition brands. For this study, 30 shots were fired, utilizing six common ammunition brands, from each of the 10 casework firearms for a total of 300 cartridge cases.

The LTAR Cropland Common Experiment at Lower Chesapeake Bay.

The Lower Chesapeake Bay (LCB) Long-Term Agroecosystem Research (LTAR) Common Experiment (CE) located in Beltsville, MD, focuses on research of concern to producers of the major regional crops, which are corn (Zea mays L.), soybean [Glycine max (L.) Merr.

Maternal Depressive Symptoms and Risk for Childhood Depression: Role of Executive Functions.

Objective: Offspring of mothers with depression are at increased risk for executive function (EF) deficits and later depressive symptoms, but limited studies have examined EF as an intermediary pathway. This study examined the role of EF in mediating the association between maternal and child depressive symptoms.

Method: Data were from a longitudinal birth cohort comprising 739 participants followed from the antenatal period for 12 years.

Alopecia Areata Treatment Patterns and Satisfaction: Results of a Real-World Cross-Sectional Survey in Europe.

Introduction: Alopecia areata (AA) is an autoimmune disease that causes scalp, face, and/or body hair loss. Recently, oral treatments with kinases inhibition became the first approved therapies for severe AA. An understanding of the use and effectiveness of traditional therapies in real-world treatment settings is needed to guide integration of novel therapies into the treatment paradigm.

Exploring research participation in Scottish care homes since the COVID-19 pandemic.

Knowledge about research participation in care homes is sparse. To explore research participation in Scottish care homes, including the potential barriers and facilitators, a short survey was distributed to all care homes in Scotland in 2014. The survey was repeated in 2022 as care homes emerged from the effects of the coronavirus disease 2019 (COVID-19) pandemic.

Toddler disorganized attachment in relation to cortical thickness and socioemotional problems in late childhood.

Disorganized attachment is a risk for mental health problems, with increasing work focused on understanding biological mechanisms. Examining late childhood brain morphology may be informative - this stage coincides with the onset of many mental health problems. Past late childhood research reveals promising candidates, including frontal lobe cortical thickness and hippocampal volume.

A longitudinal study of breastmilk feeding duration, EEG power and early academic skills.

Background: The cognitive benefits of breastfeeding are widely recognized; however, its effects on brain development and later academic skills require further examination. This study aimed to examine the longitudinal relations between breastmilk feeding, neurophysiological changes, and early academic skills.

Methods: In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort, breastmilk feeding practices were collected every 3 months from 3 weeks to 18 months postpartum.

Exploring research engagement among nurses in a Magnet®-recognized cancer center: An analysis of knowledge, attitudes, practices, and influencing factors.

Objective: Despite the significance of research in nursing practice and its role in enhancing the quality of life for cancer patients, nurses report limited opportunities to engage with research. Known barriers include limited organizational support, a lack of time, resources, and knowledgeable colleagues/mentors. The study aims to determine research knowledge, attitudes, and practices among cancer nurses and understand factors influencing nurses' involvement in research.

A social-ecological approach to support equitable land use decision-making.

Human-driven land use change can result in unequitable outcomes in the provision and appropriation of ecosystem services (ES). To better address equity-related effects of land use change in decision-making, analyses of land use and ES changes under different land use management alternatives should incorporate ecological and social information and take a disaggregated approach to ES analysis. Because such approaches are still scarce in the literature, we present a generalized social-ecological approach to support equitable land use decision-making (in terms of process and outcomes) and an example of its application to a case study in southwestern Ethiopia.

Oral care interventions for autistic individuals: A systematic review.

Oral care-related challenges are well documented in the autistic community; dental care remains one of the most prevalent unmet health needs among autistic individuals. This review examined interventions designed to improve oral health in autistic individuals from children and adult populations. Through a systematic process, 36 studies were identified.

Two-year prospective cohort of intensive care survivors enrolled on a digitally enabled recovery pathway focussed on individualised recovery goal attainment.

Background: Despite substantial evidence documenting physical, psychological, and cognitive problems experienced by intensive care unit (ICU) survivors, few studies explore interventions supporting recovery after hospital discharge. Individualised recovery goal setting, the standard of care across many rehabilitation areas, is rarely used for ICU survivors. Digital health technologies may help to address current service fragmentation and gaps.

Computer-assisted patient identification tool in inborn errors of metabolism - potential for rare disease patient registry and big data analysis.

Background: Patient registries are crucial for rare disease management. However, manual registry construction is labor-intensive and often not user-friendly. Our goal is to establish Hong Kong's first computer-assisted patient identification tool for rare diseases, starting with inborn errors of metabolism (IEM).