Virtual Lung Screening Trial (VLST): An Replica of the National Lung Screening Trial for Lung Cancer Detection.

Importance: Clinical imaging trials are crucial for evaluation of medical innovations, but the process is inefficient, expensive, and ethically-constrained. Virtual imaging trial (VIT) approach addresses these limitations by emulating the components of a clinical trial. An rendition of the National Lung Screening Trial (NCLS) via Virtual Lung Screening Trial (VLST) demonstrates the promise of VITs to expedite clinical trials, reduce risks to subjects, and facilitate the optimal use of imaging technologies in clinical settings.

Challenges of deep learning methods for COVID-19 detection using public datasets.

Since the COVID-19 pandemic, several research studies have proposed Deep Learning (DL)-based automated COVID-19 detection, reporting high cross-validation accuracy when classifying COVID-19 patients from normal or other common Pneumonia. Although the reported outcomes are very high in most cases, these results were obtained without an independent test set from a separate data source(s). DL models are likely to overfit training data distribution when independent test sets are not utilized or are prone to learn dataset-specific artifacts rather than the actual disease characteristics and underlying pathology.

DSNet: Automatic dermoscopic skin lesion segmentation.

Background And Objective: Automatic segmentation of skin lesions is considered a crucial step in Computer-aided Diagnosis (CAD) systems for melanoma detection. Despite its significance, skin lesion segmentation remains an unsolved challenge due to their variability in color, texture, and shapes and indistinguishable boundaries.

Methods: Through this study, we present a new and automatic semantic segmentation network for robust skin lesion segmentation named Dermoscopic Skin Network (DSNet).