Publications by authors named "Lavinia P Mocan"
This study aimed to assess the influence of different types of blue light sources on male and female rats' puberty onset, the morphologic-induced alterations in reproductive organs tissues, the impact on inflammation and oxidative stress markers, anxiety levels, and mathematical modeling for tissue data interpretation. Four groups of sixteen rats each (8 females and 8 males/group) were investigated: three groups were exposed to blue light from mobile phones (MP), computer screens (PC), or LED lamps (LED) versus the control group (CTRL). The rats in the CTRL group had no exposure while the other groups were exposed for 30 days to the blue light of MP, PC, and LED for 16 h per day.
View Article and Find Full Text PDFThe paper provides an overview of the current understanding of different cells and structures' biology [e.g., blood-retinal barrier, Bruch membrane, Clara (club) cells, brush cells and tuft cells, Merkel cells, Hofbauer cells, cytokeratins], including their origin, structure, function, and role in disease pathogenesis, and of the latest findings in the medical literature concerning the paracortex of the lymph nodes.
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- * Using high-throughput mass spectrometry, the study identified 845 proteins, highlighting significant differences in protein levels among the conditions, with S100A9 and haptoglobin elevated in iCCA and ICAM2 in HCC.
- * Key findings suggest that serum amyloid A proteins (SAA1 and SAA4) as well as VCAM-1 and TEK may serve as potential biomarkers for distinguishing iCCA and HCC, emphasizing the need for further validation of these findings.
Article Synopsis
- This study explored the relationship between type-I interferons (IFNs) and disease activity in primary sclerosing cholangitis (PSC) using both a mouse model and human serum samples.
- Elevated levels of bioactive type-I IFNs were found in both PSC patients and a specific mouse model, correlating with immune cell presence and liver enzyme levels, indicating potential severity of the disease.
- The findings suggest that particularly high concentrations of IFNω may point to a new inflammatory pathway related to PSC's progression and underlying mechanisms.
Statins, which are inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, are an effective pharmacological tool for lowering blood cholesterol levels. This property makes statins one of the most popular drugs used primarily to prevent cardiovascular diseases, where hyperlipidemia is a significant risk factor that increases mortality. Nevertheless, studies conducted mainly in the last decade have shown that statins might prevent and treat liver cancer, one of the leading causes of cancer-related mortality worldwide.
View Article and Find Full Text PDFThe field of hepatocellular carcinoma (HCC) has faced significant change on multiple levels in the past few years. The increasing emphasis on the various HCC phenotypes and the emergence of novel, specific therapies have slowly paved the way for a personalized approach to primary liver cancer. In this light, the role of percutaneous liver biopsy of focal lesions has shifted from a purely confirmatory method to a technique capable of providing an in-depth characterization of any nodule.
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- * This study explored the diagnostic and prognostic value of various immunohistochemical stains in iCCA patients and found that CK19 and CA19-9 were highly sensitive markers.
- * Additionally, certain factors like high CK7 expression and low intratumoral immune cells were linked to better survival outcomes for iCCA patients, according to statistical analysis.
Cholangiocarcinoma, the second most common liver malignancy, after hepatocarcinoma is highly aggressive and usually diagnosed in advanced cases. In the era of personalized medicine, targeted therapy protocols are limited for cholangiocarcinoma and the only potential curative treatment, surgical resection, is seldom applicable.This retrospective study included all cases with pathology-confirmed intrahepatic cholangiocarcinoma admitted in a tertiary healthcare facility during a 10-year timeframe.
View Article and Find Full Text PDFTo investigate the effects of PEG-coated gold nanoparticles on ablation zone volumes following in vivo radiofrequency ablation of porcine liver. This prospective study was performed following institutional animal care and committee approval was used. Radiofrequency ablations were performed in the livers of ten Sus scrofa domesticus swines.
View Article and Find Full Text PDFAim: Percutaneous radiofrequency (RFA) and microwave ablation (MWA) are currently the best treatment options forpatients with liver metastases (LM) who cannot undergo a liver resection procedure. Presently, few studies have evaluated theefficacy of tumor ablation in beginner's hands but none at all in hepatic metastasis. Our aim was to report the initial experiencewith ultrasound as a tool to guide tumor ablation in a low volume center with no experience in tumor ablation.
View Article and Find Full Text PDFAims: To report on the long-term impact of tumor and non-tumor related parameters on local recurrence, distant recurrence and survival in patients with naïve or recurrent type hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).
Methods: We performed 240 RFA sessions on 133 patients with 156 HCC nodules developed on a background of liver cirrhosis and analyzed the outcomes.
Results: Contrast-enhanced ultrasound performed one month after RFA showed complete ablation in 119 out of 133 (89.