A Hybrid Architecture (CO-CONNECT) to Facilitate Rapid Discovery and Access to Data Across the United Kingdom in Response to the COVID-19 Pandemic: Development Study.

Background: COVID-19 data have been generated across the United Kingdom as a by-product of clinical care and public health provision, as well as numerous bespoke and repurposed research endeavors. Analysis of these data has underpinned the United Kingdom's response to the pandemic, and informed public health policies and clinical guidelines. However, these data are held by different organizations, and this fragmented landscape has presented challenges for public health agencies and researchers as they struggle to find relevant data to access and interrogate the data they need to inform the pandemic response at pace.

[Multicentre rating of a delusional patient with help of the AMDP scale].

A videotaped interview of a delusional patient was evaluated by 33 French, Swiss and Belgian raters. The inverse factor analysis of the raters and multivariate indexes demonstrate in this single case study that the interrater reliability depends on: a) the general training of the raters in psychopathology; b) their knowledge of the AMDP System; c) a comprehensive understanding of the psychopathology of the patient; d) AMDP concepts; e) the interview technique (this latter deficiency may be corrected by a semi-structured interview.

[Neurological tolerance of lithium-psychotropic drugs association (author's transl)].

The authors have studied the neurological tolerance from the combination of lithium-psychotropic drugs from 265 associated cures carried out on 132 patients between 1971 and 1978. The risk of neurological inability to assimilate is not greater when haldol is combined with lithium by comparison with other combinations where it is not included. Only the presence of cerebral organicity presents a risk factor.

[Clinical significance of the erythro-plasmatic ratio of lithium (author's transl)].

Six hundred erythrocyte-plasma lithium ratios have been gathered from 67 patients presenting affective disorders. Ratios values in relapse period are not altered regarding those in remission phase as between periods with neuroleptic associations and those without. Ratios values are not noticeably modified by personality, sex and the evolution of affective disorders.

[Use of haloperidol at very high doses].

The authors report the observations of 12 patients who have been treated by haloperidol at a dose of 60 mg per os each day during periods from 15 to 106 days. They presented severe paranoid reaction with excitement. This treatment was insufficient to calm down the agitation and had to be completed by an increase of the doses in one case and by the association of an other neuroleptic in the other cases.