Neuronal computations strongly depend on inhibitory interactions. One such example occurs at the first retinal synapse, where horizontal cells inhibit photoreceptors. This interaction generates the center/surround organization of bipolar cell receptive fields and is crucial for contrast enhancement.
View Article and Find Full Text PDFIn the vertebrate retina, cones project to the horizontal cells (HCs) and bipolar cells (BCs). The communication between cones and HCs uses both chemical and ephaptic mechanisms. Cones release glutamate in a Ca(2+)-dependent manner, while HCs feed back to cones via an ephaptic mechanism.
View Article and Find Full Text PDFZebrafish is becoming an increasingly popular model in the field of visual neuroscience. Although the absorption spectra of its cone photopigments have been described, the cone action spectra were still unknown. In this study we report the action spectra of the four types of zebrafish cone photoreceptors, determined by measuring voltage responses upon light stimulation using whole cell patch clamp recordings.
View Article and Find Full Text PDFConnexins are the building blocks of gap-junctions; sign conserving electrical synapses. Recently it has been shown that connexins can also function as hemichannels and can mediate a sign inverting inhibitory synaptic signal from horizontal cells to cones via an ephaptic mechanism. In this review we will discuss the critical requirements for such an ephaptic interaction and relate these to the available experimental evidence.
View Article and Find Full Text PDFIn the vertebrate retina, horizontal cells generate the inhibitory surround of bipolar cells, an essential step in contrast enhancement. For the last decades, the mechanism involved in this inhibitory synaptic pathway has been a major controversy in retinal research. One hypothesis suggests that connexin hemichannels mediate this negative feedback signal; another suggests that feedback is mediated by protons.
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