Publications by authors named "Lauve R Y Tchokouaha"
Article Synopsis
- Antiretroviral therapy (ART) improves the lives of people with HIV/AIDS, but long-term use can lead to liver toxicity and metabolic issues, necessitating research on protective measures.
- This study evaluated the phytochemical properties of hydroethanolic extracts from PNS (plant stem) and its potential protective effects against liver damage and metabolic disorders caused by the ART regimen involving tenofovir/lamivudine/efavirenz (TLE) in rats.
- Results indicated that PNS had beneficial properties, showing decreased liver enzyme levels and improved blood parameters when compared to rats treated only with TLE, along with preservation of liver and kidney tissue integrity.
Article Synopsis
- Antiparasitic drug resistance is a significant issue in controlling malaria and leishmaniasis, particularly affecting disadvantaged populations in remote tropical regions.
- The study focused on evaluating the antimalarial and antileishmanial effects of a methanol extract from a Cameroonian medicinal plant, leading to the isolation of a new compound and several known ones.
- The extracts showed moderate to potent antileishmanial activity, with better effectiveness against multidrug-resistant parasite strains, while being less effective against chloroquine-sensitive strains.
Article Synopsis
- * A novel glucocerebroside called antroklaicerebroside was isolated, along with five previously known compounds, using advanced chromatographic techniques and characterized through NMR, MS, and IR spectroscopy.
- * Several fractions and isolated compounds were tested against chloroquine-resistant and susceptible strains of parasites, showing significant antiparasitic effects, with one compound exhibiting an impressive IC value that surpassed standard reference drugs.
Article Synopsis
- Researchers investigated the rhizomes of a plant from the Polygonaceae family and identified six anthraquinone compounds, including chrysophanol and emodin.
- These compounds were characterized using mass spectrometry (MS) and nuclear magnetic resonance (NMR) techniques by comparing them with existing literature.
- Emodin was found to have the strongest antileishmanial activity, and this study is notable for reporting the antileishmanial effects of these specific compounds for the first time.
Implementation and continued validation of the malaria Plasmodium falciparum lactate dehydrogenase-based colorimetric assay for use in antiplasmodial drug screening.
Patrick Valere Tsouh Fokou Brice Mariscal Tchatat Tali Darline Dize Cedric Derick Jiatsa Mbouna Cyrille Armel Njampa Ngansop Lauve Rachel Yamthe Tchokouaha
Anal Biochem
July 2022
Article Synopsis
- Antimalarial drug discovery has improved with in vitro testing methods, particularly the PfLDH assay, which is efficient and accessible for scientists, especially in lower-income countries.
- The study validated the PfLDH method in a lab setting using known antimalarial drugs, demonstrating strong linearity and effective detection limits.
- Results showed that the PfLDH assay is reliable, with good reproducibility and minimal variability, making it a robust option for drug screening in antimalarial research.
Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats: The Role of Leaf Extract.
Evid Based Complement Alternat Med
June 2021
Article Synopsis
- - The study investigates how a hydro-ethanolic extract from a certain leaf can prevent obesity and related health issues in rats fed a cafeteria diet, which is known to cause excessive fat accumulation.
- - Rats were divided into groups and fed either a normal diet, a cafeteria diet, or given varying doses of the extract, alongside atorvastatin as a control, with results showing significant weight gain and health deterioration in those on the cafeteria diet.
- - The extract effectively reduced weight gain, improved cholesterol levels, and provided protection against organ damage and oxidative stress, demonstrating potential as a natural treatment for obesity-related cardiovascular problems.
Article Synopsis
- Alzheimer's disease primarily causes memory loss due to changes in the cholinergic system, with current treatments being only symptomatic and having side effects.
- This study investigates the effects of an aqueous extract on memory impairment induced by Scopolamine in mice, using various behavioral tests and measuring brain enzyme activities.
- Results show that the aqueous extract improves memory and reduces oxidative stress by lowering acetylcholinesterase activity, suggesting its potential as a new therapy for Alzheimer's-related memory issues.*
Article Synopsis
- Researchers isolated a new limonoid (trigilgianin) and a new phenyl alkene (epoxy gilgialkene) from the stem bark of the Harms tree, along with five known compounds, marking the first time these have been identified in this species.
- The structures of these compounds were determined using spectral studies and comparisons with existing literature.
- Among the isolated compounds, two demonstrated significant antileishmanial activity against the visceral leishmaniasis parasite, exhibiting low cytotoxicity, while one showed moderate activity against promastigotes.
Article Synopsis
- * After eight weeks of treatment, the extract improved antioxidant levels in the heart, liver, and kidney, helping to normalize biochemical markers like AST, ALT, and urea, which were negatively affected by diabetes.
- * Histopathological analysis showed that the treated rats did not exhibit tissue damage and inflammation commonly seen in untreated diabetic rats, indicating the extract’s potential protective effects against oxidative stress and organ damage.
Article Synopsis
- The study investigates the potential of Terminalia mantaly and Terminalia superba, plants used in traditional medicine in Cameroon, as sources for new anti-malarial drugs, especially against artemisinin-resistant malaria parasites.
- Twelve extracts and fractions from these plants were tested for their effectiveness against both chloroquine-resistant and sensitive strains of Plasmodium falciparum using specific assays in a lab setting.
- Results showed that most extracts had potent antiplasmodial activities, with two extracts showing particularly high efficacy and selectivity, making them promising candidates for further drug development.
Article Synopsis
- - The lack of collaboration between academia and the pharmaceutical industry limits new drug discovery, but open source drug initiatives, like sharing physical compounds, could help bridge this gap and accelerate research.
- - The Medicines for Malaria Venture created the Malaria Box, a collection of over 400 compounds tested against malaria, which has been shared with almost 200 research groups, encouraging public data sharing on screening results.
- - Recent findings from the Malaria Box screenings revealed mechanisms of action for many compounds against various life stages of the malaria parasite, and some showed effectiveness against other pathogens and cancer cell lines, providing valuable data for further drug development.
Costus afer Possesses Carbohydrate Hydrolyzing Enzymes Inhibitory Activity and Antioxidant Capacity In Vitro.
Evid Based Complement Alternat Med
August 2015
Article Synopsis
- Diabetes mellitus is a disorder that affects how the body processes glucose and is linked to high blood sugar levels and oxidative stress, making blood sugar control crucial for management.
- The study investigated Costus afer, a medicinal plant, and found it can inhibit enzymes responsible for carbohydrate digestion, specifically α-amylase and α-glucosidase, with the best results from extracts of the rhizome and leaf.
- Various extracts of C. afer not only inhibit these enzymes but also show significant antioxidant activity, likely due to bioactive compounds like flavonoids and phenols present in the plant.
Article Synopsis
- - Toxoplasmosis and amebiasis are significant global health issues, and current treatments have limitations, prompting the need for new drug discovery methods.
- - The study screened compounds from the Medicines for Malaria Venture (MMV) Malaria Box, identifying seven promising anti-Toxoplasma compounds with strong inhibitory effects and one standout compound, MMV007791, demonstrating exceptional potency and selectivity.
- - Additionally, two compounds showed moderate activity against Entamoeba histolytica, highlighting the potential for developing novel drugs that operate through different mechanisms than existing treatments.
Composition and cytotoxic activity of essential oils from Xylopia aethiopica (Dunal) A. Rich, Xylopia parviflora (A. Rich) Benth.) and Monodora myristica (Gaertn) growing in Chad and Cameroon.
Issakou Bakarnga-Via Jean Baptiste Hzounda Patrick Valere Tsouh Fokou Lauve Rachel Yamthe Tchokouaha Magali Gary-Bobo
BMC Complement Altern Med
April 2014
Article Synopsis
- - The study explores the potential of essential oils from Monodora myristica, Xylopia aethiopica, and Xylopia parviflora as new anticancer therapies, particularly against breast cancer cells (MCF7).
- - Essential oils were analyzed using advanced techniques, revealing that they primarily contain monoterpenes, with significant cytotoxic effects observed on cancer cells compared to normal cells.
- - The oils from X. parviflora exhibited the highest selectivity and potency against the cancer cells, suggesting they warrant further research for their antineoplastic properties.
Article Synopsis
- The study investigates the anti-malarial potential of Sorindeia juglandifolia fruits, a plant from Cameroon, as previous research on its phytochemical and pharmacological properties was lacking.* -
- Fruit extracts were prepared using methanol and underwent fractionation, followed by testing against a resistant malaria strain (P. falciparum W2) and a recombinant cysteine protease, with promising safety profiles noted in mouse models.* -
- Two significant compounds, 2,3,6-trihydroxy benzoic acid and 2,3,6-trihydroxy methyl benzoate, demonstrated inhibitory activity against malaria parasites with varying potency, and compound (1) showed effectiveness in vivo against a
Article Synopsis
- Malaria endemic countries, like Cameroon, rely on medicinal plants for traditional treatments, with increasing use of various herbal species including the Annonaceae family for malaria therapy.
- Interviews conducted in four Cameroonian areas revealed that traditional healers have developed cost-effective treatments based on local knowledge and available resources.
- The study documented 30 recipes using 21 plants for malaria treatment, with Annickia chlorantha being the most commonly found plant across all sites; seven Annonaceae species were identified as directly treating malaria.