Publications by authors named "Lauryn A Brown"
Hepatic lipid accumulation, or Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is a significant risk factor for liver cancer. Despite the rising incidence of MASLD, the underlying mechanisms of steatosis and lipotoxicity remain poorly understood. Interestingly, lipid accumulation also occurs during fasting, driven by the mobilization of adipose tissue-derived fatty acids into the liver.
View Article and Find Full Text PDFIn the liver, mitochondria are exposed to different concentrations of nutrients due to their spatial positioning across the periportal and pericentral axis. How the mitochondria sense and integrate these signals to respond and maintain homeostasis is not known. Here, we combine intravital microscopy, spatial proteomics, and functional assessment to investigate mitochondrial heterogeneity in the context of liver zonation.
View Article and Find Full Text PDFArticle Synopsis
- Mitochondria in the liver display different characteristics based on their location along the periportal and pericentral axis, showing distinct functions related to nutrient processing.
- Research revealed that while beta-oxidation is more active in periportal regions, lipid synthesis is favored in pericentral mitochondria.
- The study emphasizes the significance of protein phosphorylation in regulating mitochondrial function and structure, furthering our understanding of liver metabolism and its implications for health and disease.