Publications by authors named "Laury Arazi"
Article Synopsis
- Theca cells play crucial roles in ovarian follicle growth and maturation, providing necessary structural, metabolic, and steroid-producing support.
- Researchers conducted single cell multi-omics analysis to understand the origins and differentiation of various theca cell subtypes in human antral stage follicles.
- They identified three specific types of theca cells—structural, androgenic, and perifollicular—along with a progenitor cell, contributing to a better understanding of ovarian development and potential implications for diagnosing or treating ovarian disorders.
Article Synopsis
- The development of oocytes involves a complex interplay between various ovarian cell types and regulatory signals from the hypothalamus and pituitary gland.
- Current research primarily focuses on later-stage ovarian cells due to the difficulty in accessing smaller antral follicles, which are less studied because of limited human tissue availability.
- The article presents protocols for isolating different cell types from antral follicles, allowing for detailed analysis of early follicle development and the cultivation of these cells to better understand ovarian function.
Int J Mol Sci
December 2022
Article Synopsis
- The ovarian reserve is limited and decreases from mid-gestation to menopause, affected by various factors, including genetics and environmental influences.
- Many cases of reduced ovarian reserve lead to infertility that may not be resolved by assisted reproductive technologies, highlighting the need for understanding the underlying mechanisms.
- The review emphasizes prevention strategies: primary prevention to reduce harmful exposures, selective screening for genetic risks, and tertiary prevention to manage conditions post-diagnosis for better health outcomes.
