Publications by authors named "Laury Amelia Roa Fuentes"
Eur J Oral Sci
December 2022
Article Synopsis
- Retinoic acid, an active form of vitamin A, is crucial for embryonic development, but excess levels can disrupt palate formation, leading to cleft palates in mice.
- In a study analyzing mouse embryo palate cultures, retinoic acid treatment showed a significant decrease in palate fusion rates and altered key signaling pathways, particularly increasing WNT signaling.
- The findings indicated that retinoic acid interferes with bone formation and palate development by enhancing WNT pathway activity while downregulating genes involved in bone formation.
