Long-lasting reduction of cortical blood flow of the brain after spreading depression with preserved autoregulation and impaired CO2 response.

The purpose of the present study was to examine the cerebral perfusion after spreading depression with special emphasis on its relation to the perfusion changes in migraine. The cerebrovascular reactivity to changes of arterial PCO2 tension in the range of 24-70 mm Hg and to changes of MABP in the range of 55-150 mm Hg was studied in the rat brain after one episode of cortical spreading depression. Regional CBF (rCBF) was measured in the frontal, parietal, and occipital cortex, the basal ganglia, and the cerebellum of both hemispheres after the intravenous bolus injection of [14C]iodoantipyrine.

Regional cerebral blood flow during migraine attacks by Xenon-133 inhalation and emission tomography.

Regional cerebral blood flow (rCBF) was measured by single photon emission tomography, using Xenon-133 inhalation during migraine attacks. The method yields images of three brain slices, depicting rCBF with a spatial resolution of 1.7 cm.

Regulation of regional cerebral blood flow during and between migraine attacks.

Cerebrovascular reactivity to voluntary hyperventilation, moderate hypertension, and physiological activation was studied in nine patients during induced migraine attacks and in four patients between their attacks. Regional cerebral blood flow was measured by the xenon 133 injection technique in 254 areas of one hemisphere. The partly hypoperfused hemisphere allowed for comparison of adjacent hypoperfused and normally perfused brain areas.

A case of malignant lymphoma and myasthenia gravis.

A 25-year-old man with myasthenia gravis and a non-Hodgkin lymphoma stage III B involving the thymus, is reported. The association myasthenia gravis and non-Hodgkin lymphoma has not been described previously. Treatment with chlormetin, vincristine, procarbazine, prednisone (MOPP) resulted in complete remission of both the myasthenic symptoms and the malignant lymphoma.

Changes in regional cerebral blood flow during the course of classic migraine attacks.

Regional cerebral blood flow (rCBF) following carotid arteriography was studied in thirteen patients with classic migraine. Using the 133xenon intraarterial injection method, rCBF was measured in 254 areas in one hemisphere. Nine patients developed a characteristic attack following arteriography and were examined by a series of rCBF studies, spaced by intervals of 5 to 10 minutes.

Chlormezanone in the treatment of migraine attacks: a double blind comparison with diazepam and placebo.

One hundred and fifty patients treated for an acute migraine attack all received a standard regimen consisting of metoclopramide 10 mg i.m. and--20 min later--paracetamol 1 g orally.

Persistent oligemia of rat cerebral cortex in the wake of spreading depression.

Cerebral blood flow during and after spreading depression (SD) was studied in rat brain by quantitative autoradiography. The rise of cortical blood flow during SD was followed by 20 to 25% reduction below normal after SD, lasting at least an hour. Blood flow in th putamen, thalamus, and hippocampus did not change at any time during or after SD.

Electromyography of pericranial muscles during treatment of spontaneous common migraine attacks.

In 7 patients given a standard treatment during spontaneous attacks of common migraine, activity in the temporal and sternocleidomastoid muscles was studied for 140 min. Pain and nausea ratings were taken with 20 min intervals. Baseline recordings were obtained from all patients during a period without headache and from 8 dental students without a history of migraine.

The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases. I. Observations in awake man during and following moderate blood pressure reduction.

Cerebral blood flow (CBF) and cerebral venous blood gases were studied in seven patients before, during and after intravenous sodium nitroprusside infusion. The 133Xe intra-arterial injection method was used for the CBF measurements. A dose of sodium nitroprusside (mean 1.

EEG during attacks of common and classical migraine.

The Copenhagen acute headache clinic offered an opportunity to record EEG during migraine attacks in eleven patients with common migraine and ten patients with classical migraine. The median duration of the attacks was 9 h in common migraine. Three patients were studied during prodromes of classical migraine and seven in the early headache phase.

Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine.

Regional cerebral blood flow (rCBF) was measured in 254 areas of a hemisphere with the xenon 133 intraarterial injection method. Six cases of classic migraine were followed from the normal state into the prodromal phase, and in 3 cases further into the headache phase. One patient with common migraine was similarly followed during his only classic attack.

Relative reference values for clinical chemical and haematological quantities in 'healthy' elderly people.

A search of the literature revealed a paucity of data on reference values for clinical chemical and haematological quantities in reasonably 'healthy' ambulant persons above 65 years of age. On the basis of 90 papers, concerning 37 different types of quantities, the median values for men and for women at 30, 50, 65, and 80 years are calculated relative to the value in men at 30 years. This transformation reduces influences of analytical and demographic factors that have caused considerable systematic differences in the original data.

Regional cerebral blood flow during rest and skilled hand movements by xenon-133 inhalation and emission computerized tomography.

Regional cerebral blood flow (CBF) was studied in 16 normal adult volunteers during rest and in 10 the study was repeated during skilled hand movements. A fast-rotating ("dynamic"), single-photon emission computerized tomograph (ECT) with four detector heads was used. Xenon-133 was inhaled over a 1-min period at a concentration of 10 mCi/L.

Orbital bruits and retinal artery pressure in internal carotid artery occlusion.

Four patients are reported with orbital bruits. They had minor neurological deficits and all proved to have occlusion of the contralateral internal carotid artery. In three of the patients the retinal artery pressures were normal with no side to side difference, whereas pressure was slightly reduced on the occluded side in one patient.

Eaton-Lambert syndrome and malignant thymoma.

Eaton-Lambert syndrome is most frequently associated with small-cell carcinoma of the lung. We describe the first case of this disorder in a patient with malignant thymoma. Guanidine treatment had no clinical or electrophysiologic effects.

Studies on the native forms of renin in the rat kidney.

This paper describes Sephadex G-100 chromatography of rat kidney extract containing various enzyme inhibitors. The high molecular weight renin (molecular weight above 50 000) constitutes about 50% of the total renin activity. Omission of the enzyme inhibitors yield solely low molecular weight renin.

A comparison of the properties of renin isolated from pig and rat kidney.

1. On isoelectric focusing, renin from rat kidneys showed three activity peaks with pI values at pH 5.0, 5.