Publications by authors named "Laurione Candido De Oliveira"
Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion: a case-control study.
Sao Paulo Med J
March 2022
Background: Because normal male sexual differentiation is more complex than normal female sexual differentiation, there are more cases of disorders of sex development (DSDs) with 46,XY karyotype that have unclear etiology. However, Leydig and Sertoli cell markers are rarely used in distinguishing such individuals.
Objectives: To evaluate the function of Leydig and Sertoli cells in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion.
Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia.
Horm Res Paediatr
February 2019
Background: Testicular adrenal rest tumors (TART) can cause infertility in congenital adrenal hyperplasia (CAH) males.
Aims: To determine TART prevalence in patients with CAH due to 21-hydroxylase deficiency (21-OHD) and evaluate possible factors associated with its development.
Methods: This is a descriptive and analytical cross-sectional study evaluating males with the classical form of 21-OHD through testicular ultrasonography and serum inhibin B dosages.
Comparison between two inhibin B ELISA assays in 46,XY testicular disorders of sex development (DSD) with normal testosterone secretion.
J Pediatr Endocrinol Metab
January 2018
Article Synopsis
- * The study examined serum inhibin B levels in 29 patients diagnosed with various forms of 46,XY DSD using two different ELISA assays (Beckman-Coulter and AnshLabs).*
- The results showed a high interclass correlation (0.915), but significant discrepancies between the assays suggest that the same kit should be used for consistent measurements in patients.*
Article Synopsis
- This study analyzed 408 cases of disorders of sex development (DSD) with ambiguous genitalia over a 23-year period, focusing on diagnosis, age of referral, karyotype, and sex of rearing.
- The majority of cases were 46,XY (61.3%), with common conditions including testicular DSD and ovarian DSD, while congenital adrenal hyperplasia was the leading cause.
- The average age for diagnosis was 31.7 months, with a final sex of rearing predominantly male (238 cases) and only a small percentage (6.6%) requiring sex reassignment.
Purpose: Positive impact of weight loss on sexual function and hormones has been demonstrated, and male fertility in this scenario is to be better defined. We evaluated the impact of lifestyle modifications and gastric bypass on sperm quality.
Methods: We prospectively studied 20 morbidly obese men during 24 months, randomized for intervention: lifestyle modifications (exercise and diet) for 4 months and subsequently gastric bypass (n = 10); and control: follow-up (n = 10).
Objective: To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage.
Subjects And Methods: We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.
Objective: To report the experience regarding patients with steroid 5alpha-reductase type 2 deficiency from three different clinical services in Brazil.
Casuistic And Methods: Twenty five patients with clinical and hormonal features of 5alpha-reductase deficiency from 23 families (15 from Bahia, 7 from São Paulo and 1 from Minas Gerais) were included in this study. Clinical, hormonal and molecular data were evaluated.