Activity of acute pancreatitis is modified by secreted protein acidic and rich in cysteine ablation.

Background: Acute pancreatitis (AP) is a frequent cause for hospitalization. However, molecular determinants that modulate severity of experimental pancreatitis are only partially understood.

Objective: To investigate the role of secreted protein acidic and rich in cysteine (SPARC) during cerulein-induced AP in mice.