Risk of hemorrhage during surgical evacuation for second-trimester intrauterine fetal demise.

Objective: To assess risk of hemorrhage during surgical evacuation for intrauterine fetal demise (IUFD).

Methods: We compared hemorrhage associated with surgical evacuation for IUFDs ≥14weeks to surgical evacuations for other indications.

Results: From 12/2005 to 4/2013, 477 in-hospital surgical evacuations met inclusion criteria (123 IUFD, 354 comparators).

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

The generation of pluripotent stem cells from an individual patient would enable the large-scale production of the cell types affected by that patient's disease. These cells could in turn be used for disease modeling, drug discovery, and eventually autologous cell replacement therapies. Although recent studies have demonstrated the reprogramming of human fibroblasts to a pluripotent state, it remains unclear whether these induced pluripotent stem (iPS) cells can be produced directly from elderly patients with chronic disease.