Publications by authors named "Laurien Czichon"
Article Synopsis
- Early infection dynamics are critical for understanding host-pathogen interactions, but studying these in human lungs is challenging; thus, researchers analyzed human lung tissue cultured from patients with emphysema to observe the immediate responses to various pathogens.
- Pseudomonas aeruginosa was found to induce the most significant changes in RNA expression, particularly affecting microRNA, with influenza A virus (IAV) showing a distinct RNA signature linked to its infection response.
- Both bacterial pathogens elicited similar mRNA expression changes, yet P. aeruginosa's impact was stronger; the study identified six key mRNAs that form the core response to IAV, highlighting differences in how various pathogens trigger lung tissue reactions.
