Corrigendum: Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions .

[This corrects the article DOI: 10.3389/fimmu.2018.

Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions .

Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In an analysis using an engineered AAV virus carrying immune-dominant SIINFEKL peptide in the capsid backbone, we have previously demonstrated that capsid antigen presentation from full (genome containing) AAV capsids requires endosome escape and is proteasome dependent and that no capsid antigen presentation is induced from empty virions.