Publications by authors named "Laurie L Metcalfe"
Am J Vet Res
February 2024
Article Synopsis
- The study aimed to identify protective VP8 epitopes of equine rotavirus and test whether immunizing hens with synthetic peptides could produce effective neutralizing antibodies for foals.
- Researchers used white leghorn hens to generate high-titer anti-VP8 antibodies, which were then evaluated for their ability to neutralize the virus.
- The findings showed that administering hyperimmune egg yolk antibodies to foals with rotaviral diarrhea was safe and suggests potential for further study on their therapeutic benefits.
J Vet Intern Med
November 2021
Article Synopsis
- - A study compared the effectiveness of two types of hyperimmune plasma—PNAG HIP and RE HIP—in protecting foals from R. equi pneumonia, showing that PNAG HIP had better lab results but had not been tested in real-world conditions.
- - In a controlled clinical trial involving 460 foals, both groups received transfusions of either RE HIP or PNAG HIP shortly after birth and were monitored for pneumonia symptoms.
- - The findings revealed no significant difference in pneumonia development between the two groups, indicating that PNAG HIP is not more effective than the established RE HIP for preventing the disease in foals.
