Case Series in the Utility of Invasive Blood Pressure Monitoring in Microvascular Decompression.

Background: The utility of arterial lines in microvascular decompression (MVD) is not well described.

Objective: To examine the safety and costs of arterial lines compared with noninvasive blood pressure (NIBP) monitoring in MVDs.

Methods: We retrospectively reviewed patients undergoing MVD from 2012 to 2020.

A phase Ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy.

Background: We performed the first multiple dose study of remimazolam designed to assess both the feasibility of maintaining suitable sedation during colonoscopy and reversing the sedative effects of remimazolam with flumazenil.

Methods: Healthy volunteers received fentanyl followed by remimazolam for sedation during colonoscopy. Three dose groups of 15 volunteers each received remimazolam in increasing initial doses, plus top-up doses to maintain sedation for a 30-minute period.

A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics.

Background: A new benzodiazepine, remimazolam, metabolized by tissue esterases to an inactive compound, CNS 7054, has been developed to permit a fast onset, a short and more predictable duration of sedative action, and a more rapid recovery profile than with currently available benzodiazepines. We report on the safety and efficacy of the first human study.

Methods: A phase I, single-center, double-blind, placebo- and active-controlled, randomized, single-dose escalation study was conducted.