Alteration of the Fetal Heart Rate Pattern Induced by the Use Of Clozapine during Pregnancy.

Patients treated with clozapine show autonomic dysregulation and cardiac repolarisation changes. As clozapine crosses the placenta, it could have an impact on the fetus heart rate. We reported a case of reduction of the fetal heart rate variability in a patient treated with clozapine during her pregnancy.

Photodynamic therapy of ovarian cancer peritoneal metastasis with hexaminolevulinate: a toxicity study.

Context: While photodynamic therapy (PDT) is a promising treatment for peritoneal carcinomatosis, its use is often limited because of the toxicity of photosensitizers. In this study, safety of PDT with hexaminoevulinate (HAL), a second generation photosensitizer, is assessed.

Methods: PDT of the peritoneal cavity was performed in a rat model of peritoneal carcinomatosis.

Development of a new illumination procedure for photodynamic therapy of the abdominal cavity.

A homogeneous illumination of intra-abdominal organs is essential for successful photodynamic therapy of the abdominal cavity. Considering the current lack of outstanding light-delivery systems, a new illumination procedure was assessed. A rat model of peritoneal carcinomatosis was used.

Photodiagnosis and photodynamic therapy of peritoneal metastasis of ovarian cancer.

Ovarian cancer is among the deadliest in women. Current treatment strategies fail to cure many patients owing to the difficulties of eradicating peritoneal implants frequently associated with this pathology. Photodynamic therapy represents a promising treatment as it offers many advantages over alternative strategies: diagnostic properties, specific targeting of abnormal cells, possibility to be combined with other therapies.