Publications by authors named "Laurie Destruel"
Background: Little is known about susceptibility of Staphylococcus lugdunensis to antiseptics. The objective of this study was to evaluate, at the molecular and phenotypic level, the susceptibility of 49 clinical S. lugdunensis strains (belonging to the seven clonal complexes [CCs] defined by multilocus sequence typing) to two antiseptics frequently used in healthcare settings (chlorhexidine digluconate [CHX] and chloride benzalkonium [BAC]).
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- The study focuses on the role of the LytSR two-component regulatory system (TCS) in the virulence of a coagulase-negative staphylococcus, especially in biofilm-related infections.
- Deleting the LytSR system led to decreased biofilm formation, characterized by lower biomass and increased dead cells, and significantly reduced virulence in a slow-killing assay.
- The results indicate that LytSR influences the expression of 286 genes related to metabolism and virulence factors, highlighting its importance in bacterial pathogenesis.