Publications by authors named "Laurie Bean"
Article Synopsis
- A single-laboratory validation (SLV) study was performed on a microplate receptor binding assay (RBA) to measure paralytic shellfish poisoning (PSP) toxins using [3H]saxitoxin (STX) for comparison with STX in shellfish samples.
- The assay demonstrated high accuracy, with a half-maximal inhibition (IC50) of 2.3 nM STX and a limit of quantification of 5.3 microg STX equivalents per 100 g of shellfish, confirming reliable measurement of PSP toxicity.
- Method comparisons revealed strong correlations between the RBA and traditional AOAC mouse bioassay methods, indicating that the RBA is a valid alternative for assessing PSP toxin
