Publications by authors named "Lauridsen K"
Article Synopsis
- Advances in treating classic Hodgkin lymphoma (cHL) have led to an 80% overall survival rate, but survivors face risks of long-term complications like cardiac and pulmonary issues.
- Research using advanced protein analysis compared samples from cHL patients with and without bleomycin-induced pulmonary toxicity (BPT), revealing distinct protein expression and disrupted pathways linked to BPT risk.
- Key proteins like JAK3, BID, and MMP9 were found at different levels in patients with BPT, indicating that certain protein profiles in biopsies might predict poorer survival outcomes in these individuals.
Follicular lymphoma (FL) is the most common low-grade lymphoma. Despite its indolent nature, FL carries an inherent risk of histological transformation (HT) to a more aggressive lymphoma. Existing biomarkers are insufficient to predict HT, indicating the need for more robust biological predictors.
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- The study investigates the north-south gradient hypothesis, suggesting that individuals with rheumatoid arthritis (RA) in southern regions (like Turkey) tend to have a younger age of onset and milder disease than those in northern regions (like Denmark).
- In a comparison of 223 treatment-naïve RA patients from Denmark and Turkey, it was found that Danish patients had a later onset age (60 years) and more severe joint symptoms compared to Turkish patients (51 years).
- The findings support the hypothesis and reveal that Danish patients have more genetic risk factors for RA, prompting the need for future research into the genetic and environmental influences on these regional differences.
Article Synopsis
- The eighth annual summary from the International Liaison Committee on Resuscitation (ILCOR) focuses on the latest findings in cardiopulmonary resuscitation (CPR) and emergency cardiovascular care, building on a comprehensive review from 2020.
- This summary is based on the evaluation of recent resuscitation evidence by experts from six different ILCOR task forces, who utilized specific criteria to assess the quality of evidence and reached consensus treatment recommendations.
- The document also identifies key areas where more research is needed, sharing insights into the task forces’ discussions through sections like Justification and Evidence-to-Decision Framework Highlights.
This is the eighth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations; a more comprehensive review was done in 2020. This latest summary addresses the most recent published resuscitation evidence reviewed by the International Liaison Committee on Resuscitation task force science experts. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, using Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations.
View Article and Find Full Text PDFFollicular lymphoma (FL) is characterized by an indolent nature and generally favorable prognosis, yet poses a particular clinical challenge, since disease progression is observed in a notable subset of patients. Currently, it is not possible to anticipate which patients will be at risk of progression, highlighting the need for reliable predictive biomarkers that can be detected early in the disease. We applied tandem-mass-tag labelled nano-liquid chromatography tandem mass spectrometry (nLC-MS/MS) on 48 diagnostic formalin-fixed, paraffin-embedded tumor samples from patients with advanced-stage FL.
View Article and Find Full Text PDFClassic Hodgkin lymphoma (CHL) is a highly curable disease, even in advanced stages. Controversy remains over whether bone involvement negatively affects overall and progression-free survival in patients treated with intensive chemotherapy regimens. Whether cases that present with bone lesions harbor specific tumor microenvironmental features is unknown.
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- The study investigates the link between cardiac output (CO) and hypertension disorders during pregnancy, specifically preeclampsia, in women with and without fetal growth restriction (FGR).
- In a cohort of 906 pregnant women, findings suggest that low CO is a significant risk factor for preeclampsia, especially in those below 37 weeks of gestation, with women having FGR being at an even higher risk.
- The research highlights the potential importance of monitoring third-trimester cardiovascular function to identify women at risk for preeclampsia, although more studies are needed to confirm these findings.
Article Synopsis
- A population of neurons in the ventral tegmental area (VTA) co-transmit two neurotransmitters, glutamate and GABA, but their inputs and functions are not fully understood.
- Using advanced tracing techniques in mice, researchers discovered that these neurons receive diverse inputs from various brain regions, with significant inputs from the superior colliculus and lateral hypothalamus.
- Optical activation of these inputs revealed that lateral hypothalamus involvement leads to active behavior, while superior colliculus stimulation results in brief activation and freezing behavior, indicating the complex integration of signals by VTA neurons related to motivation and behavior.
Article Synopsis
- The mannose receptor (MR/CD206) is found on M2-like tumor-associated macrophages and can be released into the bloodstream as soluble CD206 (sCD206), which is measurable in serum.
- In a study with 88 metastatic renal cell carcinoma (mRCC) patients, serum sCD206 levels were found to be higher in intermediate-risk patients compared to healthy controls and those with favorable risk scores.
- High baseline levels of sCD206 were linked to poorer overall survival outcomes, and incorporating sCD206 into existing risk assessments improved the classification of patients in the intermediate-risk group.
Article Synopsis
- Individuals with HIV have a heightened risk of developing lymphoma, a significant cause of death, but the genetic factors involved are not well understood.
- Researchers performed next-generation sequencing on lymphoma biopsies from 18 HIV-infected patients to analyze the genetic mutations present in these tumors.
- The study revealed a diverse range of 213 genetic variants across the lymphomas, with no consistent mutations shared among all cases, indicating complex genetic heterogeneity in HIV-associated lymphomas.
We conducted a systematic review to assess if any condition before- or after simulation-based training of teamwork competencies for healthcare professionals affects learning or transfer of skills to the clinical environment.We searched CINAHL, Medline, and Embase for studies published between January 1, 2011, and July 10, 2023. We screened 13,149 abstracts and 335 full texts, of which 5 studies were included.
View Article and Find Full Text PDFTo evaluate tumour necrosis factor inhibitor (TNFi) drug-levels and presence of anti-drug antibodies (ADAb) in patients with inflammatory arthritis who taper TNFi compared to TNFi continuation. Patients with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis on stable TNFi dose and in low disease activity ≥ 12 months were randomised (2:1) to disease activity-guided tapering or control. Blood samples at baseline, 12- and 18-months were evaluated for TNFi drug-levels and ADAb.
View Article and Find Full Text PDFObjectives: To evaluate the effectiveness of life support training with specific emphasis on team competencies on clinical and educational outcomes.
Methods: This systematic review was prospectively registered (PROSPERO CRD42023473154) and followed the PICOST (population, intervention, comparison, outcome, study design, timeframe) format. All randomized controlled trials and non-randomized studies evaluating learners undertaking life support training with specific emphasis on team competencies in any setting (actual and simulated resuscitations) were included.
Importance: Termination of resuscitation (TOR) rules may help guide prehospital decisions to stop resuscitation, with potential effects on patient outcomes and health resource use. Rules with high sensitivity risk increasing inappropriate transport of nonsurvivors, while rules without excellent specificity risk missed survivors. Further examination of the performance of TOR rules in estimating survival of out-of-hospital cardiac arrest (OHCA) is needed.
View Article and Find Full Text PDFObjective: We aimed to investigate the association of recent team leader simulation training (<6 months) and years of clinical experience (≥4 years) with chest compression quality during in-hospital cardiac arrest (IHCA).
Methods: This cohort study of IHCA in four Danish hospitals included cases with data on chest compression quality and team leader characteristics. We assessed the impact of recent simulation training and experienced team leaders on longest chest compression pause duration (primary outcome), chest compression fraction (CCF), and chest compression rates within guideline recommendations using mixed effects models.
Background: Improving survival from pediatric cardiac arrest requires a well-functioning system of care with appropriately trained healthcare providers and designated cardiac arrest teams. This study aimed to describe the current organization and training for pediatric cardiac arrest in Denmark.
Methods: We performed a nationwide cross-sectional study.
Background: The association between chest compression (CC) pause duration and pediatric in-hospital cardiac arrest survival outcomes is unknown. The American Heart Association has recommended minimizing pauses in CC in children to <10 seconds, without supportive evidence. We hypothesized that longer maximum CC pause durations are associated with worse survival and neurological outcomes.
View Article and Find Full Text PDFBackground: Defibrillation is essential for achieving return of spontaneous circulation (ROSC) following out-of-hospital cardiac arrest (OHCA) with shockable rhythms. This study aimed to investigate if the type of defibrillator used was associated with ROSC in OHCA.
Methods And Results: This study included adult patients with OHCA from the Danish Cardiac Arrest Registry from 2016 to 2021 with at least 1 defibrillation by the emergency medical services.
Objective: This study aimed to compare the prevalence and incidence of polyautoimmunity between anticyclic citrullinated peptide antibody (anti-CCP)-positive and anti-CCP-negative patients with rheumatoid arthritis (RA).
Methods: In a nationwide register-based cohort study, patients with RA (disease duration ≤ 2 yrs) in the DANBIO rheumatology register with an available anti-CCP test in the Register of Laboratory Results for Research were identified. The polyautoimmunity outcome included 21 nonrheumatic autoimmune diseases identified by linkage between the Danish Patient Registry and Prescription Registry.
Nurturing the development of the next generation of resuscitation scientists is essential for creating a vibrant and enabled community equipped with the necessary knowledge, attitudes, and skills to transform resuscitation practice and improve outcomes. In this concept paper we will describe the development and implementation of the first Young European Resuscitation Council Resuscitation Science Masterclass. The masterclass aims to connect, inspire, and support the growth of the next generation of resuscitation scientists through education, networking, and joint scientific work.
View Article and Find Full Text PDFBackground: Simulation has become a staple in the training of healthcare professionals with accumulating evidence on its effectiveness. However, guidelines for optimal methods of simulation training do not currently exist.
Methods: Systematic reviews of the literature on 16 identified key questions were conducted and expert panel consensus recommendations determined using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology.