Pathogenic Variant in Lynch Syndrome-Associated Colorectal Cancer with Polyps.

 Lynch syndrome (LS) is an autosomal dominant condition due to the germline mutation in the mismatch repair (MMR) genes including , , and (post-meiotic segregation increased 2). The MMR mutation carriers have high risk for cancers. Pathogenic variants are rarely reported in LS-associated colorectal cancer (CRC) with colorectal polyps.