Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome and Chemical Validation of Combination Strategies for Respiratory Inhibitors against .

cytochrome quinol oxidase (cyt ), the alternative terminal oxidase of the respiratory chain, has been identified as playing a key role during chronic infection and presents a putative target for the development of novel antitubercular agents. Here, we report confirmation of successful heterologous expression of cytochrome . The heterologous cytochrome expression system was used to identify a chemical series of inhibitors based on the 2-aryl-quinolone pharmacophore.