Management pathways for the successful reduction of nonpoint source nutrients in coastal ecosystems.

Eutrophication remains a threat to coastal habitats and water quality worldwide. The U.S.

Metagenomic sequencing of stool samples in Bangladeshi infants: virome association with poliovirus shedding after oral poliovirus vaccination.

The potential role of enteric viral infections and the developing infant virome in affecting immune responses to the oral poliovirus vaccine (OPV) is unknown. Here we performed viral metagenomic sequencing on 3 serially collected stool samples from 30 Bangladeshi infants following OPV vaccination and compared findings to stool samples from 16 age-matched infants in the United States (US). In 14 Bangladeshi infants, available post-vaccination serum samples were tested for polio-neutralizing antibodies.

Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis.

Background: Bacterial vaginosis affects 15 to 50% of women of reproductive age, and recurrence is common after treatment with an antibiotic agent. The high incidence of recurrence suggests the need for new treatments to prevent recurrent bacterial vaginosis.

Methods: We conducted a randomized, double-blind, placebo-controlled, phase 2b trial to evaluate the ability of CTV-05 (Lactin-V) to prevent the recurrence of bacterial vaginosis.

How much is too much? Identifying benchmarks of adverse effects of macroalgae on the macrofauna in intertidal flats.

Eutrophication, defined as the accumulation of organic matter typically in response to anthropogenically enhanced nutrient inputs, often takes the form of macroalgal blooms in shallow estuaries and causes a cascade of adverse ecosystem effects. Confidence in the use of macroalgae as an indicator of eutrophication in estuaries is limited by the lack of quantitative data on thresholds of adverse effects. Field experiments can provide "benchmarks" of no effect or adverse effects that can be used to validate thresholds derived statistically from field data.

Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties.

Introduction: Elevated lipoprotein(a) (Lp(a)) levels were reported to be associated with dense fibrin clots. The apo(a) component of Lp(a) is encoded by LPA, and the Met allele of the LPA Ile4399Met polymorphism is associated with elevated Lp(a) levels and cardiovascular disease risk. We investigated whether Ile4399Met was associated with fibrin clot properties.

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.

Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels of triglyceride (TG) in mice. In humans, APOA5 genetic variation is associated with TG in several populations. In this study, we determined the effects of the p.