Publications by authors named "Lauri A Hunsucker"
Article Synopsis
- Oklahoma has lower cancer mortality rates than 33 other states despite a higher cancer incidence, highlighting the urgent need to study cancer trends in its high-risk populations.
- The study used data from OK2SHARE to analyze cancer rates by urban and rural classifications, revealing notable differences in cancer types and insurance coverage.
- Results indicate that rural areas face higher mortality rates from various cancers, particularly lung cancer, emphasizing the necessity for better cancer detection and treatment in these regions.
Objective: Mebendazole and other anti-parasitic drugs are being used off-prescription based on social media and unofficial accounts of their anti-cancer activity. The purpose of this study was to conduct a controlled evaluation of mebendazole's therapeutic efficacy in cell culture and in vivo models of ovarian cancer. The majority of ovarian cancers harbor p53 null or missense mutations, therefore the effects of p53 mutations and a mutant p53 reactivator, PRIMA-1 (APR246) on mebendazole activity were evaluated.
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