Publications by authors named "Laurent S Baccar"

Head and neck cancer is particular due to its infiltrative nature and lymphatic extension, with multidisciplinary treatment. Immunotherapy may be a brand-new therapeutic approach. We report a case of patient with advanced head and neck cancer resistant to cytotoxic treatment, with astonishing response to antibodies anti Programmed Death 1 (PD1).

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Article Synopsis
  • * In a case report, two patients with advanced uterine leiomyosarcomas showed significant progression-free survival (PFS) and overall survival (OS) after receiving Trabectedin as their second and third line treatment.
  • * The first patient had a PFS of 24 months and OS of 35 months receiving third line treatment, while the second had a similar PFS of 24 months but an OS of 30 months; both experienced good safety outcomes and quality of life during long-term Trabectedin administration.
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Metastasis of non-gynaecological tumours to the cervix is a rare event, and metastasis from breast cancer is even rarer, with only a limited number of such cases reported in the literature to date. We herein report the case of an 86-year-old female patient who had undergone mastectomy and axillary lymphadenectomy for invasive ductal cell breast carcinoma 2 years prior, followed by adjuvant hormonal therapy with letrozole. During hospitalization for anemia associated with an inflammatory syndrome and abdominal pain with menorrhagia, an abdominal ultrasound examination revealed a suspicious uterine mass with irregular contours and abnormal vascularization with associated increase of the blood level of cancer antigen 15-3 to 34 kU/l.

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