Structured Treadmill Training as a Strategy to Mitigate Tumor Growth and Preserve Adipose tissue and Muscle Strength in Prostate Tumor Bearing Mice.

Purpose: Exercise is widely recognized for providing numerous benefits to prostate cancer (PCa) survivors. Numerous preclinical studies have investigated the role of exercise on tumor progression, but results are often controversial, largely due to variations in experimental protocols.

Methods: In this study, the comprehensive effects of exercise on PCa were evaluated with two different aerobic exercises, forced and structured Exercise Training on treadmill (ET), and Voluntary Wheel Running (VWR).

Voluntary Wheel Running Does Not Enhance Radiotherapy Efficiency in a Preclinical Model of Prostate Cancer: The Importance of Physical Activity Modalities?

Physical activity is increasingly recognized as a strategy able to improve cancer patient outcome, and its potential to enhance treatment response is promising, despite being unclear. In our study we used a preclinical model of prostate cancer to investigate whether voluntary wheel running (VWR) could improve tumor perfusion and enhance radiotherapy (RT) efficiency. Nude athymic mice were injected with PC-3 cancer cells and either remained inactive or were housed with running wheels.

"Should I stay or should I go now?" Recovery time effect on walking capacity in symptomatic peripheral artery disease.

The objective of the study was to investigate the effect of recovery time on walking capacity (WC) throughout repeated maximal walking bouts in symptomatic lower-extremity peripheral artery disease (PAD). The effect of recovery time on WC (maximal walking time) was determined in 21 participants with PAD in three experimental conditions [recovery time from 0.5 to 9.