Unifying Effects of Direct and Relational Associations for Visual Communication.

People have expectations about how colors map to concepts in visualizations, and they are better at interpreting visualizations that match their expectations. Traditionally, studies on these expectations (inferred mappings) distinguished distinct factors relevant for visualizations of categorical vs. continuous information.

Context Matters: A Theory of Semantic Discriminability for Perceptual Encoding Systems.

People's associations between colors and concepts influence their ability to interpret the meanings of colors in information visualizations. Previous work has suggested such effects are limited to concepts that have strong, specific associations with colors. However, although a concept may not be strongly associated with any colors, its mapping can be disambiguated in the context of other concepts in an encoding system.

The relation between color and spatial structure for interpreting colormap data visualizations.

Interpreting colormap visualizations requires determining how dimensions of color in visualizations map onto quantities in data. People have color-based biases that influence their interpretations of colormaps, such as a dark-is-more bias-darker colors map to larger quantities. Previous studies of color-based biases focused on colormaps with weak data spatial structure, but color-based biases may not generalize to colormaps with strong data spatial structure, like "hotspots" typically found in weather maps and neuroimaging brain maps.

Semantic Discriminability for Visual Communication.

To interpret information visualizations, observers must determine how visual features map onto concepts. First and foremost, this ability depends on perceptual discriminability; observers must be able to see the difference between different colors for those colors to communicate different meanings. However, the ability to interpret visualizations also depends on semantic discriminability, the degree to which observers can infer a unique mapping between visual features and concepts, based on the visual features and concepts alone (i.

Estimating Color-Concept Associations from Image Statistics.

To interpret the meanings of colors in visualizations of categorical information, people must determine how distinct colors correspond to different concepts. This process is easier when assignments between colors and concepts in visualizations match people's expectations, making color palettes semantically interpretable. Efforts have been underway to optimize color palette design for semantic interpretablity, but this requires having good estimates of human color-concept associations.

Design considerations for the enhancement of human color vision by breaking binocular redundancy.

To see color, the human visual system combines the response of three types of cone cells in the retina-a compressive process that discards a significant amount of spectral information. Here, we present designs based on thin-film optical filters with the goal of enhancing human color vision by breaking its inherent binocular redundancy, providing different spectral content to each eye. We fabricated a set of optical filters that "splits" the response of the short-wavelength cone between the two eyes in individuals with typical trichromatic vision, simulating the presence of approximately four distinct cone types.

Color inference in visual communication: the meaning of colors in recycling.

People interpret abstract meanings from colors, which makes color a useful perceptual feature for visual communication. This process is complicated, however, because there is seldom a one-to-one correspondence between colors and meanings. One color can be associated with many different concepts (one-to-many mapping) and many colors can be associated with the same concept (many-to-one mapping).

PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers.

Diet affects the risk and progression of prostate cancer, but the interplay between diet and genetic alterations in this disease is not understood. Here we present genetic evidence in the mouse showing that prostate cancer progression driven by loss of the tumor suppressor Pten is mainly unresponsive to a high-fat diet (HFD), but that coordinate loss of the protein tyrosine phosphatase Ptpn1 (encoding PTP1B) enables a highly invasive disease. Prostate cancer in Pten(-/-)Ptpn1(-/-) mice was characterized by increased cell proliferation and Akt activation, interpreted to reflect a heightened sensitivity to IGF-1 stimulation upon HFD feeding.

The CASC15 Long Intergenic Noncoding RNA Locus Is Involved in Melanoma Progression and Phenotype Switching.

In recent years, considerable advances have been made in the characterization of protein-coding alterations involved in the pathogenesis of melanoma. However, despite their growing implication in cancer, little is known about the role of long noncoding RNAs in melanoma progression. We hypothesized that copy number alterations (CNAs) of intergenic nonprotein-coding domains could help identify long intergenic noncoding RNAs (lincRNAs) associated with metastatic cutaneous melanoma.

Prostate cancer genetic-susceptibility locus on chromosome 20q13 is amplified and coupled to androgen receptor-regulation in metastatic tumors.

Unlabelled: The 20q13 chromosomal region has been previously identified as the hereditary prostate cancer genetic-susceptibility locus on chromosome 20 (HPC20). In this study, the 20q13 region was shown to be frequently co-amplified with the androgen receptor (AR) in metastatic prostate cancer. Furthermore, the AR signaling axis, which plays an essential role in the pathogenesis of prostate cancer, was demonstrated to be central to the regulation of the 20q13 common amplified region (CAR).

Large-scale independent validation of the nuclear factor-kappa B p65 prognostic biomarker in prostate cancer.

Purpose: Over the last decade, we and others have uncovered a robust association between the nuclear localisation of nuclear factor-kappa B (NF-κB) p65, prostate cancer (PCa) aggressiveness and biochemical recurrence (BCR). Our goal was to validate these results in a large independent cohort of PCa patients who underwent radical prostatectomy.

Experimental Design: A set of 1826 fully annotated prostate cancers treated by radical prostatectomy were analysed in a tissue microarray (TMA) format for NF-κB p65 immunohistochemistry-based protein expression.

Heterogeneous epigenetic regulation of TIMP3 in prostate cancer.

Tissue inhibitor of metalloproteinase-3 (TIMP3) is a tumor suppressor gene frequently downregulated in prostate cancer. The mechanisms involved in TIMP3 transcriptional repression are not fully understood, but evidence suggests that promoter hypermethylation may not be the predominant epigenetic alteration in prostate cancer. To clarify this issue, we examined the contribution of both CpG site promoter methylation and histone modifications on TIMP3 downregulation.

PTP1B is an androgen receptor-regulated phosphatase that promotes the progression of prostate cancer.

The androgen receptor (AR) signaling axis plays a key role in the pathogenesis of prostate cancer. In this study, we found that the protein tyrosine phosphatase PTP1B, a well-established regulator of metabolic signaling, was induced after androgen stimulation of AR-expressing prostate cancer cells. PTP1B induction by androgen occurred at the mRNA and protein levels to increase PTP1B activity.

The two faces of PTP1B in cancer.

PTP1B is a classical non-transmembrane protein tyrosine phosphatase that plays a key role in metabolic signaling and is a promising drug target for type 2 diabetes and obesity. Accumulating evidence also indicates that PTP1B is involved in cancer, but contrasting findings suggest that it can exert both tumor suppressing and tumor promoting effects depending on the substrate involved and the cellular context. In this review, we will discuss the diverse mechanisms by which PTP1B may influence tumorigenesis as well as recent in vivo data on the impact of PTP1B deficiency in murine cancer models.

Warm-started wavefront reconstruction for adaptive optics.

Future extreme adaptive optics (ExAO) systems have been suggested with up to 10(5) sensors and actuators. We analyze the computational speed of iterative reconstruction algorithms for such large systems. We compare a total of 15 different scalable methods, including multigrid, preconditioned conjugate-gradient, and several new variants of these.

NF-kappaB2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells.

Several reports suggest that androgen signalling interferes with canonical RelA-p50 activity in androgen-sensitive cells. Whether this also occurs with non-canonical NF-kappaB subunits has not been studied. Here we report that androgenic stimulation of LNCaP cells with the androgen analogue R1881 appears to positively regulate the non-canonical NF-kappaB pathway as p52 accumulates both in the cytoplasm and nucleus after 48-72 h of stimulation.

Regulation of IkappaB kinase epsilon expression by the androgen receptor and the nuclear factor-kappaB transcription factor in prostate cancer.

Although several genes have been associated with prostate cancer progression, it is clear that we are far from understanding all the molecular events implicated in the initiation and progression of the disease to a hormone-refractory state. The androgen receptor is a central player in the initiation and proliferation of prostate cancer and its response to hormone therapy. Nuclear factor-kappaB has important proliferative and antiapoptotic activities that could contribute to the development and progression of cancer cells as well as resistance to therapy.

Nuclear localization of nuclear factor-kappaB p65 in primary prostate tumors is highly predictive of pelvic lymph node metastases.

Purpose: Lymph node invasion (LNI) is associated with increased risk of prostate cancer progression. Unfortunately, pelvic lymph node dissections are fraught with a high rate of false-negative findings, emphasizing the need for highly accurate markers of LNI. Because nuclear factor-kappaB (NF-kappaB) is a candidate marker of prostate cancer progression, we tested the association between nuclear localization of NF-kappaB in radical prostatectomy specimens and the presence of LNI.

[NFkappaB : a new marker kappable of predicting prostate cancer outcome].

Prostate cancer is the most commonly diagnosed malignancy and the third cause of cancer-related death in Canadian men. Although most tumors are detected at an early stage and treated efficiently, a number of these cases will progress to a metastatic and hormone-refractory state where therapeutic options are essentially palliative. Due to a limited number of clinical prognostic markers, it is often difficult to identify cancers at risk of progression.

An androgen-independent androgen receptor function protects from inositol hexakisphosphate toxicity in the PC3/PC3(AR) prostate cancer cell lines.

Background: Inositol hexakisphosphate (IP6) is a phytochemical exhibiting anticancer activity. Because few prostate cancer (PCa) cell lines have been used to study IP6, we assessed its efficacy in a panel of PCa cell lines.

Methods And Results: Using WST-1 assays we observed that, although androgens did not modulate its efficacy, IP6 was more active in androgen receptor (AR) negative cells than in AR-positive cells.