Keratoconus and the Impact of Treatment on Patients' Quality of Life: A Qualitative Study.

Introduction: Keratoconus has a significant impact on patients' quality of life (QoL), from diagnosis to the advanced stages of the disease. The aim of this research was to identify domains of QoL affected by this disease and its treatment.

Methods: Phone interviews were conducted using a semi-structured interview guide, with patients with keratoconus stratified according to their current treatment.

Postoperative Corneal Epithelial Remodeling After Intracorneal Ring Segment Procedures for Keratoconus: An Optical Coherence Tomography Study.

Purpose: To assess epithelial corneal remodeling by anterior segment optical coherence tomography (AS-OCT) after intracorneal ring segments (ICRS) implantation in keratoconic eyes.

Methods: This prospective observational study included patients with keratoconus receiving ICRS of different arc lengths according to their tomographic pattern. AS-OCT and corneal topography (Scheimpflug camera) were performed before and 1, 3, and 6 months after surgery.

Corneal Remodeling After Myopic SMILE: An Optical Coherence Tomography and In Vivo Confocal Microscopy Study.

Purpose: To study corneal remodeling during the first 6 months after myopic small incision lenticule extraction (SMILE) with a 10% overcorrection nomogram, by spectral-domain optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM).

Methods: This prospective non-randomized observational study included 60 eyes from 30 patients treated by SMILE for low to moderate myopia. A 10% overcorrection nomogram was applied for all eyes.

Presbyopia management with Q-factor modulation without additive monovision: One-year visual and refractive results.

Purpose: To analyze refractive results after hyperopic presbyopia surgery by Q-factor modulation without additive monovision.

Setting: Quinze-Vingts National Ophthalmology Hospital, Paris, France.

Design: Prospective nonrandomized study.

Deep Intrastromal Arcuate Keratotomy With In Situ Keratomileusis (DIAKIK) for the Treatment of High Astigmatism After Keratoplasty: 2-Year Follow-up.

Purpose: To describe 2-year results of deep intrastromal arcuate keratotomy with in situ keratomileusis (DIAKIK) for the treatment of high astigmatism after keratoplasty.

Methods: This prospective study included 20 eyes from 20 patients presenting with high astigmatism after keratoplasty. All were treated by two-step femtosecond laser surgery, with two intrastromal arcuate keratotomies and a corneal flap, followed a few months later by excimer photoablation after reopening of the flap.

True exposure to lead at the tap: Insights from proportional sampling, regulated sampling and water use monitoring.

This work aimed to evaluate the ability of four regulatory sampling protocols to accurately determine weekly water lead levels (WLLs) of exposure at the kitchen tap in twenty-nine households with or without a lead service line (LSL). Proportional sampling was used as the gold standard to which the other protocols, 5-min flush, 30-min stagnation, 6-h stagnation and random daytime were compared. Random daytime samples provided mean WLLs closest to true exposure in the households monitored overall compared to other sampling protocols.

Genetic Analysis of the Organization, Development, and Plasticity of Corneal Innervation in Mice.

The cornea has the densest sensory innervation of the body, originating primarily from neurons in the trigeminal ganglion. The basic principles of cornea nerve patterning have been established many years ago using classic neuroanatomical methods, such as immunocytochemistry and electrophysiology. Our understanding of the morphology and distribution of the sensory nerves in the skin has considerably progressed over the past few years through the generation and analysis of a variety of genetically modified mouse lines.

Persistent corneal fibrosis after explantation of a small-aperture corneal inlay.

The KAMRA small-aperture corneal inlay can compensate for presbyopia. A small number of complications have been reported, including glare, halos, decentration, iron deposition, compromised distance and night vision, infectious keratitis and reversal corneal haze. We describe a case of corneal fibrosis after small-aperture corneal inlay implantation and its persistence after late explantation.

Lead and copper release from full and partially replaced harvested lead service lines: Impact of stagnation time prior to sampling and water quality.

Partial lead service line replacement (PLSLR) results in the addition of a new galvanic connection and can increase lead concentrations at the tap. Focus has been given to minimizing lead release after PLSLR, but little information is available on the impact of lead remedial actions on copper concentrations, especially before passivation occurs. The impact of water quality (decreased chloride-to-sulfate mass ratio from 0.

Study of the long-term impacts of treatments on lead release from full and partially replaced harvested lead service lines.

Long-term (155 weeks) Pb concentrations, following partial lead service lines replacements (PLSLR), were measured in a flow through pilot made of harvested lead service lines (LSL) from the distribution system of the City of Montreal. The present study also investigates how release of Pb from full and partial LSLs is influenced by: pipe diameter, decrease in chloride-to-sulfate mass ratio (CSMR) from 0.9 to 0.

Contribution of Fourier-domain optical coherence tomography to the diagnosis of keratoconus progression.

Purpose: To determine the anatomic criteria for diagnosing keratoconus progression by corneal optical coherence tomography (OCT).

Setting: Quinze-Vingts National Ophthalmology Hospital, Paris, France.

Design: Prospective case series.

Early Epithelial Remodeling After Standard and Iontophoresis-Assisted Corneal Cross-linking as Evaluated by Spectral-Domain Optical Coherence Tomography.

Purpose: To evaluate and compare epithelial remodeling after standard corneal cross-linking (S-CXL) and iontophoresis-assisted CXL (I-CXL) in eyes with keratoconus by anterior segment optical coherence tomography (AS-OCT).

Methods: In this prospective, observational study, AS-OCT and corneal topography were performed before and 1, 3, and 6 months after surgery. Corneal pachymetry was performed and epithelial and stromal thicknesses (central and 16 points on the 6-mm central zone) and the maximum simulated keratometry value (Kmax) were measured.

Lead Levels at the Tap and Consumer Exposure from Legacy and Recent Lead Service Line Replacements in Six Utilities.

Profile, regulatory, and investigative sampling were completed in six utilities to study the impact of partial and full lead service line replacements (LSLRs) on water lead levels (WLLs) and consumer's exposure. As compared to households with no replacement, lead release after partial LSLR (PLSLR) was generally greater in the short term (3-50 days), and comparable or lower in the medium (<2 years) and long-term (>2 years). This was mainly explained by insufficient time elapsed to stabilize scales after disturbances to the service line.

Unilateral corneal ectasia after small-incision lenticule extraction in a 43-year-old patient.

Unilateral corneal ectasia developed after small-incision lenticule extraction for mild myopia in a 43-year-old man with preoperative asymmetric astigmatism. The ectasia was diagnosed 4 years postoperatively. Preoperative data showed asymmetric astigmatism with no signs of forme fruste keratoconus.

Integrase-Mediated Recombination of the Gene Cassette Encoding the Extended-Spectrum β-Lactamase BEL-1.

Integrons are genetic elements that can acquire and rearrange gene cassettes. The gene encodes an extended-spectrum β-lactamase, BEL-1, that is present at the second position of the variable region of class 1 integrons identified in The mobility of the gene cassette was analyzed under physiological conditions and with the integrase gene being overexpressed. Cassette mobility in was detected by excision/integration into the recipient integron In on the conjugative plasmid R388 with the overproduced integrase.

Corneal Neurotization With a Great Auricular Nerve Graft: Effective Reinnervation Demonstrated by In Vivo Confocal Microscopy.

Purpose: We describe the first case of minimally invasive corneal neurotization with the great auricular nerve (GAN) to treat unilateral neurotrophic keratopathy. We assessed corneal sensation and reinnervation by esthesiometry and confocal microscopy over 12 months of follow-up, and we provide a detailed description of the surgical technique.

Methods: Corneal neurotization was successfully achieved with the ipsilateral GAN in a 58-year-old woman.

Short- and Long-Term Lead Release after Partial Lead Service Line Replacements in a Metropolitan Water Distribution System.

Thirty-three households were monitored in a full-scale water distribution system, to investigate the impact of recent (<2 yr) or old partial lead service line replacements (PLSLRs). Total and particulate lead concentrations were measured using repeat sampling over a period of 1-20 months. Point-of-entry filters were installed to capture sporadic release of particulate lead from the lead service lines (LSLs).

New parameters in assessment of human donor corneal stroma.

Purpose: To provide quantitative parameters for assessment of human donor corneal stroma by imaging stromal features of diseased and normal human corneas with full-field optical coherence microscopy (FFOCM), using confocal microscopy (CM) and histology as reference techniques.

Methods: Bowman's layer (BL) thickness and keratocyte density were assessed ex vivo in 23 human donor corneas and 27 human pathological corneas (keratoconus and other corneal disorders) with FFOCM, CM and histology. Stromal backscattering was assessed with FFOCM.

Conventional and Iontophoresis Corneal Cross-Linking for Keratoconus: Efficacy and Assessment by Optical Coherence Tomography and Confocal Microscopy.

Purpose: To compare the efficacy, safety, and microstructural corneal changes during 2 years after conventional corneal collagen cross-linking (C-CXL) and transepithelial corneal CXL by iontophoresis (I-CXL) for keratoconus.

Methods: Eighty eyes of 80 patients with progressive keratoconus were treated by C-CXL (n = 40) or I-CXL (n = 40). Patients were investigated before surgery and 1, 3, 6, 12, and 24 months after treatment.

Increased corneal sub-basal nerve density in patients with Sjögren syndrome treated with topical cyclosporine A.

Background: To evaluate quantitative and qualitative changes in sub-basal corneal nerves (SBN) via in vivo confocal microscopy in patients with Sjögren syndrome dry eye (SSDE) treated with topical cyclosporine A (CsA).

Design: Prospective, observational, non-randomized study.

Participants: Thirty eyes of 30 patients with SSDE refractory to conventional treatment treated with CsA 0.

Bilateral infectious keratitis after small-incision lenticule extraction.

Unlabelled: We report the clinical features and management of a patient with severe bilateral infectious keratitis developing after simultaneous bilateral small-incision lenticule extraction. A 39-year-old man was referred to our emergency department 2 days after a small-incision lenticule extraction procedure for moderate myopia. He reported decreased vision, photophobia, and pain bilaterally.

Iris-fixated phakic intraocular lens implantation to correct myopia and a predictive model of endothelial cell loss.

Purpose: To report long-term results of Artisan phakic intraocular lens (pIOL) to correct myopia and to propose a model predicting endothelial cell loss after pIOL implantation.

Setting: Quinze-Vingts National Ophthalmology Hospital, Paris, France.

Design: Retrospective, interventional case series.

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis.

Keratoconus is a bilateral and progressive corneal ectasia. In order to slow down its progression, corneal collagen cross-linking (CXL) has recently been introduced as an efficient treatment option. In biological and chemical sciences, crosslinking refers to new chemical bonds formed between reactive molecules.

Decreased Corneal Sensation and Subbasal Nerve Density, and Thinned Corneal Epithelium as a Result of 360-Degree Laser Retinopexy.

Purpose: To assess the effects of 360-degree laser retinopexy on human corneal subbasal nerve plexus and to investigate correlations among corneal subbasal nerve plexus density, corneal epithelial thickness, and corneal sensitivity.

Design: Prospective, observational, nonrandomized study.

Participants: A total of 15 eyes of 15 patients who underwent pars plana vitrectomy (PPV) with 360-degree laser retinopexy for retinal detachment (RD) and 15 eyes of 15 patients who underwent PPV for macular hole (MH) without laser treatment.