Intra-abdominal adipose depot variation in adipogenesis, lipogenesis, angiogenesis, and fibrosis gene expression and relationships with insulin resistance and inflammation in premenopausal women with severe obesity.

Although severe obesity is associated with insulin resistance (IR) and inflammation, secretory function of intra-abdominal adipose tissues and their relationships with IR and inflammation markers remain poorly understood. Aims were to measure gene expression of adipogenic (C/EBPα/β, PPARγ-1/2, SREBP-1c, LXRα), lipogenic (SCD1, DGAT-1/2), angiogenic (VEGFα, leptin), and fibrotic (LOX, COL6A3) factors in the round ligament (RL), omental (OM), and mesenteric (ME) fat depots and to evaluate their relationships with IR and inflammation markers in 48 women with severe obesity undergoing bariatric surgery. Gene expression was assessed by RT-qPCR, and plasma glucose and insulin (HOMA-IR calculated), PAI-1, IL-6, TNFα, adiponectin, and leptin levels were determined.

Relationship between sestamibi uptake, parathyroid hormone assay, and nuclear morphology in primary hyperparathyroidism.

Background: Technetium-99m-sestamibi scanning and the intraoperative intact parathyroid hormone (iPTH) assay have permitted development of focused parathyroid techniques for treatment of primary hyperparathyroidism. The purpose of this study was to assess if any pre- and intraoperative factors (degree of sestamibi uptake and iPTH levels) were associated with postoperative results (resected gland weight and parathyroid nuclear morphology).

Study Design: We performed a retrospective analysis of 101 consecutive patients who underwent preoperative sestamibi scintigraphy and a targeted parathyroid exploration for primary hyperparathyroidism.