Publications by authors named "Laurent Calvel"

Article Synopsis
  • * Conducted at 19 pain and palliative care centers, the study found significant reductions in pain ratings from baseline to day 14, indicating that patients experienced relief.
  • * The results showed that half of the participants responded positively to the treatment, with no serious adverse effects reported, supporting the idea of using low-dose methadone as a helpful addition to pain management strategies for cancer patients.
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Introduction: Cancer has become a chronic disease thanks to therapeutic evolutions and justifies the early integration of supportive care in the management. The Advanced Practice Nurse (APN) was created to respond to the increase in the number of patients followed in the long term. The objective of this study is to identify the place and expected missions of an APN within a multidisciplinary supportive care team.

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Objectives: The goal of palliative care is to relieve suffering and provide the best possible quality of life for patients and their families. We looked for individual factors related to a poor-quality end-of-life pathway in patients followed in palliative care.

Methods: We included all the patients followed in palliative care in Strasbourg deceased from October to December of 2020.

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Article Synopsis
  • A group of experts held a meeting to talk about how to take care of cancer patients in the ICU (Intensive Care Unit) using different medical methods.*
  • They discussed important questions about what type of support patients need, like oxygen, breathing help, and blood treatment, depending on their complications and health conditions.*
  • The meeting helped create guidelines on how to best treat cancer patients and what kind of training doctors need to provide this special care.*
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Artificial lighting, day-length changes, shift work, and transmeridian travel all lead to sleep-wake disturbances. The nychthemeral sleep-wake cycle (SWc) is known to be controlled by output from the central circadian clock in the suprachiasmatic nuclei (SCN), which is entrained to the light-dark cycle. Additionally, via intrinsically photosensitive retinal ganglion cells containing the photopigment melanopsin (Opn4), short-term light-dark alternations exert direct and acute influences on sleep and waking.

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Sleep deprivation, in the context of shift work, is an increasing major public health issue. We aimed to determine whether early light administration can counteract sleep deprivation effects, and to compare LED-glasses with a traditional light therapy box. This cross-over design study included 18 individuals exposed to light therapy for 30 minutes at 5 am after one night of complete sleep deprivation, to mimic the night shift condition.

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Aim: Identified Palliative Care Beds (Lits Identifiés Soins Palliatifs - LISPs) is a French specificity. Primarily created to integrate palliative care culture into conventional hospital units, the relevance of this measure became a controversial issue. Nowadays, hospital teams continue to frequently encounter complex situations regarding medical care for palliative patients.

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Narcolepsy type 1 is a rare disabling sleep disorder mainly characterized by excessive daytime sleepiness and cataplexy, an emotion-triggered sudden loss of muscle tone. Patients have a selective degeneration of hypocretin-producing neurons in the dorsolateral posterior hypothalamus with growing evidence supporting the hypothesis of an autoimmune mechanism. Few case studies that reported intravenous immunoglobulin therapy (IVIg) suggest the efficacy of IVIg when administered early after disease onset, but the results are controversial.

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Objectives: Anxiety and adjustment disorders are among the most prevalent mental health conditions. This review focuses on γ-aminobutyric acid receptor type A (GABAR)-mediated anxiolysis, describing the action of both endogenous and exogenous modulators of GABAR. Future directions and innovative strategies to alleviate anxiety symptoms are discussed, with a particular emphasis on etifoxine.

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Background: although neonatal pain management has seen huge improvements in the past years, many gaps between knowledge and practice still exist.

Objective: to give the reader the state of the art of actual pain management and treatment.

Methods: a literature review was done on the physiopathology of pain, sex differences in the perception of pain, epidemiology, non-pharmacological treatment and developmental care approach, pharmacological treatment with pharmacokinetics and pharmacodynamics approaches.

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Study Objectives: Sleep neurobiology studies use nocturnal species, mainly rats and mice. However, because their daily sleep/wake organization is inverted as compared to humans, a diurnal model for sleep studies is needed. To fill this gap, we phenotyped sleep and waking in Arvicanthis ansorgei, a diurnal rodent widely used for the study of circadian rhythms.

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