Publications by authors named "Laurene Gantzer"
Background And Objectives: Previous studies have reported a possible prodrome in multiple sclerosis (MS) defined by nonspecific symptoms including mood disorder or genitourinary symptoms and increased health care use detected several years before diagnosis. This study aimed to evaluate agnostically the associations between diseases and symptoms diagnosed in primary care and the risk of MS relative to controls and 2 other autoimmune inflammatory diseases with similar population characteristics, namely lupus and Crohn disease (CD).
Methods: A case-control study was conducted using electronic health records from the Health Improvement Network database in the United Kingdom and France.
Antibiotic prescription in ambulatory care for COVID-19 patients: a cohort analysis in four European countries.
Eur J Clin Microbiol Infect Dis
January 2024
Article Synopsis
- Objective: The study aims to analyze and compare antibiotic prescription rates for COVID-19 patients among general practitioners in France, the UK, Belgium, and Romania by examining 4.5 million electronic prescribing records.
- Methods: Researchers evaluated antibiotic prescription data from 3,656 GPs across the four countries, looking specifically at rates during COVID-19 consultations and categorizing the types of antibiotics prescribed.
- Results: France and Belgium showed higher overall prescription rates (6.66% and 7.46%), with significant variation in prescribing patterns, notably in Romania where a majority of GPs prescribed antibiotics despite lower overall rates, and a notable preference for azithromycin in all countries except the UK.
Article Synopsis
- Essential tremor (ET) is a common neurological disorder, and this study aimed to analyze its treatment patterns and characteristics in newly diagnosed patients in France and the UK from 2015 to 2018.
- Out of 2957 patients in the UK and 3249 in France, about 40% received treatment after diagnosis, but only 20% continued the treatment by the end of the follow-up, with many switching or stopping medications altogether.
- The findings indicate that ET is often undertreated, particularly among patients with psychiatric conditions, prompting a need for better identification and management of the disorder.
Objective: The purpose of this study was to simultaneously contrast prediagnostic clinical characteristics of individuals with a final diagnosis of dementia with Lewy Bodies (DLB), Parkinson's disease (PD), and Alzheimer's disease (AD) compared with controls without neurodegenerative disorders.
Methods: Using the longitudinal THIN database in the United Kingdom, we tested the association of each neurodegenerative disorder with a selected list of symptoms and broad families of treatments, and compared the associations between disorders to detect disease-specific effects. We replicated the main findings in the UK Biobank.
Objective: To define the factors associated with overprescription of antibiotics by general practitioners (GPs) for patients diagnosed with COVID-19 during the first wave of the pandemic.
Methods: Anonymised electronic prescribing records of 1370 GPs were analysed. Diagnosis and prescriptions were retrieved.
Importance: Suboptimal adherence to endocrine therapy (ET) among patients with hormone-receptor-positive breast cancer significantly affects survival outcomes and is associated with higher hospitalization rates and health care costs. Weak adherence to long-term treatments has multiple determinants, including disease characteristics, treatment adverse effects, and patients' attributes, such as age and comorbidities.
Objective: To examine whether potential drug-drug interactions (PDDI) with tamoxifen or aromatase inhibitor were associated with adherence to ET in patients with early and advanced breast cancer.
Article Synopsis
- - The study investigates the incidence of essential tremor (ET), a common movement disorder, in the UK and France from 2014 to 2019 using data from the Health Improvement Network database.
- - A total of around 5,000 new cases were identified in both countries, revealing an average crude incidence rate of approximately 18.20 in the UK and 21.42 in France, with higher rates typically seen in males and older age groups.
- - Despite similar standardized incidence rates in both countries, an increasing trend was noted, particularly among individuals aged 60 years and older, highlighting the necessity for further research on ET's impact on healthcare resources and disease management.
Background: The identification of modifiable risk factors for Alzheimer's disease is paramount for early prevention and the targeting of new interventions. We aimed to assess the associations between health conditions diagnosed in primary care and the risk of incident Alzheimer's disease over time, up to 15 years before a first Alzheimer's disease diagnosis.
Methods: In this agnostic study of French and British health records, data from 20 214 patients with Alzheimer's disease in the UK and 19 458 patients with Alzheimer's disease in France were extracted from The Health Improvement Network database.
Introduction: We aim to understand how patients with Alzheimer's disease (AD) are treated by identifying in a longitudinal fashion the late-life changes in patients' medical history that precede and follow AD diagnosis.
Methods: We use prescription history of 34,782 patients followed between 1996 and 2019 by French general practitioners. We compare patients with an AD diagnosis, patients with mild cognitive impairment (MCI), and patients free of mental disorders.
Background And Aims: Untreated Familial Hypercholesterolemia (FH) leads to premature morbidity and mortality. In France, its epidemiology and management are understudied in ambulatory care. We described the clinical profile, pharmacological management, and clinical outcomes in a French sample of FH patients.
View Article and Find Full Text PDF, the main cause of community-acquired pneumonia (CAP), also leads to exacerbations, hospitalizations, and mortality in chronic obstructive pulmonary disease (COPD) and congestive heart failure (CHF). The risk of CAP is increased in patients with diabetes mellitus (DM), and the risk of invasive pneumococcal disease is increased in HIV-infected patients. Pneumococcal vaccination is recommended for these patients in France.
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