Publications by authors named "Laurence Zhang"
Article Synopsis
- - Oligodendroglioma tumors are defined by specific mutations (IDH1/IDH2) and genetic deletions (1p/19q), with altered metabolism leading to increased levels of monounsaturated fatty acids and ceramides, promoting cell death.
- - The study reveals that inhibiting an enzyme called acid ceramidase (AC) can trigger apoptosis in IDH1 oligodendroglioma cells, enhancing survival rates in mice models.
- - The treatment with a drug named SABRAC showed significant effectiveness in causing cancer cell death by increasing ceramide levels, indicating a strong potential for AC as a target for future oligodendroglioma therapies.
Elevated SCD1 expression has been associated with enhanced cancer cell survival, proliferation, and resistance to therapy in many cancer types including gliomas. Hereby, we investigate the impact of MF-438 on SCD1-mediated lipid metabolism and its consequences on glioma growth and survival. Our data reveals an IDH -specific inhibitory effect of MF438 on gliomas.
View Article and Find Full Text PDFSeveral lines of evidence suggest that excessive reactive oxygen species-induced oxidative damage may underlie cognitive impairment in psychiatric disorders. A growing body of evidence show that oxidative damage may relate to the range of cognitive deficits associated with schizophrenia. In this study we examine one of the primary antioxidant defense enzymes manganese superoxide dismutase (MnSOD), and whether it relates to cognitive deficits in schizophrenia.
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