Publications by authors named "Laurence Orlando"
Article Synopsis
- The study examines the fluidisation and aerosolisation processes in a split capsule dry powder inhaler, specifically using a GSK Rotahaler(®).
- It employs dynamic real-time techniques, like laser diffraction and high-speed imaging, to assess the effects of lactose carrier characteristics on powder fluidisation, entrainment, and de-agglomeration.
- Major findings indicate that the split capsule significantly affects powder emission mechanisms, and there's a strong correlation between powder permeability and aerosolisation efficiency, suggesting that permeability testing could predict drug delivery performance.
Combining an amino acid and a sugar is a known strategy in the formulation of spray or freeze dried biomolecule powder formulations. The effect of the amino acid leucine in enhancing performance of spray-dried powders has been previously demonstrated, but interaction effects of several constituents which may provide multiple benefits, are less well-understood. A 3 factor 2 level (2(3)) factorial design was used to study the effects of leucine, glycine and alanine in a mannitol-based dry powder formulation on particle size, aerosolisation, emitted dose and cohesion.
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