Publications by authors named "Laurence Homyrda"
Article Synopsis
- - This study investigates how immune and inflammatory responses relate to outcomes in severely ill burn patients, specifically examining their association with mortality and secondary infections by analyzing biomarkers over several weeks.
- - Results showed that burn injuries resulted in increased adaptive immunity while suppressing innate immunity, and high levels of interleukin-10 (IL-10) at admission were linked to a higher risk of death.
- - Although immune response patterns didn't directly indicate mortality early on, changes later in the immune/inflammatory responses were linked to bacterial infections and septic shock, suggesting that poor immune recovery could signal a worse prognosis.
Metastatic melanoma is a rapidly spreading cancer whose prognosis remains poor although important therapy advances in recent years. Ipilimumab, an anti-CTLA-4 immunotherapy used in advanced melanoma, is an effective immunotherapy alone or combined with other agents but with few predictive biomarkers of response. Here, we sought to analyze the potential of S100B, MIA, soluble MICA, anti-MICA antibodies and LDH as serum biomarkers of response and survival in a cohort of 77 advanced melanoma patients subjected to ipilimumab.
View Article and Find Full Text PDFThe diverse aspects of cutaneous T-cell lymphomas may impede the diagnosis of Sézary syndrome (SS) and mycosis fungoides (MF), in particular, at early stages of the disease. We defined the CD158k/KIR3DL2 molecule as a first positive cell surface marker for Sézary cells (SCs). Here, we designed an optimized flow cytometry gating strategy, allowing the definition of lymphocytes of different sizes and defects of cell surface markers.
View Article and Find Full Text PDFPurpose: Our aims were to assess the feasibility of imaging hypoxia in cervical carcinoma with (18)F-fluoroerythronitroimidazole ((18)F-FETNIM) and to compare (18)F-FETNIM uptake with metabolic uptake of (18)F-FDG.
Patients And Methods: We included 16 patients with cervical carcinoma. After imaging with FDG, (18)F-FETNIM PET/CT was performed and tumor-to-muscle (T/M) ratio uptake was assessed.