Publications by authors named "Laurence Guilloux"

Article Synopsis
  • - The study investigated immediate hypersensitivity reactions (IH) to iodinated and gadolinium-based contrast media (ICM; GBCM), focusing on differentiating between allergic and non-allergic responses, which is crucial for future medical treatment decisions.
  • - Over 245 patients were analyzed through skin tests and other clinical evaluations, revealing an allergic reaction rate of 19.6% for ICM and 27.8% for GBCM, with notable cross-reactivity among patients.
  • - The findings indicated that allergic IH was linked to more severe reactions and quicker onset than non-allergic IH, highlighting the need for more sensitive skin testing methods to better identify allergic responses to contrast agents.
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Peanut, soybean, sesame and lentil are members of legumes worldwide consumed by human that can induce food allergy in genetically predisposed individuals. Several protein allergens, mainly water-soluble, have been described. We studied the non water-soluble fraction from these 4 food sources using immunoproteomics tools and techniques.

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Background: We identified a case of quinolone allergic hypersensitivity associated with quaternary ammonium (QA) sensitization, the allergic determinant of neuromuscular blocking agents (NMBAs). Concomitant sensitization to several chemically different drugs is rarely reported and raises the question of a nonfortuitous association.

Objective: We evaluated a potential association between quinolone immediate allergic hypersensitivity and NMBA sensitization.

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The common cypress (Cupressus sempervirens) (Cups) pollen represents the first cause of respiratory allergies in the Mediterranean basin. The aim of this study was to characterize a novel 14-kDa cypress pollen allergen (BP14) allowing a clear dissociation of IgE sensitization patterns among allergic patients. The biochemical and immunochemical characterization of BP14 included determination of its isoelectric point, molecular mass, extraction kinetics, IgE binding prevalence, the presence of bromelain-type cross-reactive carbohydrate determinant and its IgE reactivity under reducing conditions.

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Italian cypress (Cupressus sempervirens, Cups) pollen causes allergic diseases in inhabitants of many of the cities surrounding the Mediterranean basin. However, allergens of Cups pollen are still poorly known. We introduce here a novel proteomic approach based on double one-dimensional gel electrophoresis (D1-DE) as an alternative to the 2-DE immunoblot, for the specific IgE screening of allergenic proteins from pollen extracts.

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