Physicochemical and hydration properties of different cereal and legume gluten-free powders.

Background: The wetting and hydration stage is the key step in manufacture process of several cereal-based products. Knowledge of hydration properties of gluten-free ingredients can contribute to improve the quality of gluten-free products. The objective of the present work was to investigate hydration properties for a large variety of gluten-free ingredients.

Assessment of formulation robustness for nano-crystalline suspensions using failure mode analysis or derisking approach.

The small particle size of nano-crystalline suspensions can be responsible for their physical instability during drug product preparation (downstream processing), storage and administration. For that purpose, the commercial formulation needs to be sufficiently robust to various triggering conditions, such as ionic strength, shear rate, wetting/dispersing agent desorption by dilution, temperature and pH variation. In our previous work we described a systematic approach to select the suitable wetting/dispersant agent for the stabilization of nano-crystalline suspension.

Engineering of nano-crystalline drug suspensions: employing a physico-chemistry based stabilizer selection methodology or approach.

This paper describes a systematic approach to select optimum stabilizer for the preparation of nano-crystalline suspensions of an active pharmaceutical ingredient (API). The stabilizer can be either a dispersant or a combination of dispersant and wetting agent. The proposed screening method is a quick and efficient way to investigate a large number of stabilizers based on the principles of physical-chemistry and employs a stepwise approach.

Determination of the wettability of powders by the Washburn capillary rise method with bed preparation by a centrifugal packing technique.

The Washburn capillary rise method is a standard technique for determining the wettability of powders expressed as a contact angle. The method requires the preparation of two identical beds of powder. One of these beds is used to follow the capillary rise with a perfectly wetting liquid (contact angle = 0) giving access to a bed structure parameter.