Mechanism of action of -encoded type I toxins in : from membrane alterations to mesosome-like structures formation and bacterial lysis.

SprF1 is a type I toxin-antitoxin system located on prophage. It has previously been shown that the two toxins, SprG1 and SprG1, encoded by the gene, are two membrane-associated peptides structured in a single α-helix. Overexpression of these two peptides leads to growth inhibition and even death.

Correction: Nonin-Lecomte et al. Bacterial Type I Toxins: Folding and Membrane Interactions. 2021, , 490.

The authors wish to make the following corrections to their paper [...

Bacterial Type I Toxins: Folding and Membrane Interactions.

Bacterial type I toxin-antitoxin systems are two-component genetic modules that encode a stable toxic protein whose ectopic overexpression can lead to growth arrest or cell death, and an unstable RNA antitoxin that inhibits toxin translation during growth. These systems are widely spread among bacterial species. Type I antitoxins are - or -encoded antisense small RNAs that interact with toxin-encoding mRNAs by pairing, thereby inhibiting toxin mRNA translation and/or inducing its degradation.