Publications by authors named "Laurence Desmond"
Thromb Haemost
April 2003
Article Synopsis
- Unilateral ureteral obstruction (UUO) in mice models accelerated renal tubulointerstitial fibrosis, revealing that mice without the bradykinin B2-receptor were more prone to fibrosis.
- ACE-inhibition was effective in reducing renal fibrosis induced by UUO, but the study found no significant difference in fibrosis levels between B2-receptor positive and negative mice, indicating that the B2-receptor may not play a role in ACE-inhibition's antifibrotic effects.
- Overall, ACE-inhibitors outperformed AT1 receptor antagonists in mitigating fibrosis in both types of mice.
