Publications by authors named "Laurence Convert"
Article Synopsis
- - The study focuses on developing a non-invasive deep-learning model (DLIF) that predicts a usable input function for dynamic positron emission tomography (PET) in small animal research, specifically mice, without needing arterial blood sampling.
- - The DLIF model was trained on 68 mouse scans and tested against an external dataset of 8 scans, showing similar results to traditional methods, although some discrepancies were noted due to differences in experimental setups.
- - The findings suggest that the DLIF method could replace the complex and invasive arterial cannulation process, enabling more comprehensive and repeated PET imaging studies in mice.
Quantification of physiological parameters in preclinical pharmacokinetic studies based on nuclear imaging requires the monitoring of arterial radioactivity over time, known as the arterial input function (AIF). Continuous derivation of the AIF in rodent models is very challenging because of the limited blood volume available for sampling. To address this challenge, an Ultra High Sensitivity Blood Counter (UHS-BC) was developed.
View Article and Find Full Text PDFUnlabelled: Small-animal nuclear imaging modalities have become essential tools in the development process of new drugs, diagnostic procedures, and therapies. Quantification of metabolic or physiologic parameters is based on pharmacokinetic modeling of radiotracer biodistribution, which requires the blood input function in addition to tissue images. Such measurements are challenging in small animals because of their small blood volume.
View Article and Find Full Text PDFNew radiotracer developments for nuclear medicine imaging require the analysis of blood as a function of time in small animal models. A microfluidic device was developed to monitor the radioactivity concentration in the blood of rats and mice in real time. The microfluidic technology enables a large capture solid angle and a reduction in the separation distance between the sample and detector, thus increasing the detection efficiency.
View Article and Find Full Text PDFUnlabelled: Radiotracer kinetic modeling in small animals with PET allows absolute quantification of physiologic and biochemical processes in vivo. It requires blood and tissue tracer concentrations as a function of time. Manual sampling, the reference method for blood tracer concentration measurements, requires fairly large amounts of blood besides being technically difficult and time-consuming.
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