Concentrations of dehydroepiandrosterone-sulphate (DHEA-S) in people with cystic fibrosis on and off elexacaftor-tezacaftor-ivacaftor.

Background: Levels of sulfated Dehydroepiandrosterone (DHEA-S) are unknown in people with Cystic Fibrosis (pwCF). DHEA-S is reported to have an inverse association with inflammation and warrants evaluation in pwCF.

Methods: We compared differences in DHEA-S and other hormones between pwCF (n = 180) and without CF (n = 180) and DHEA-S association with percent predicted forced expiratory volume in one second (ppFEV1).

Unbiased characterization of atrial fibrillation phenotypic architecture provides insight to genetic liability and clinically relevant outcomes.

Background: Atrial Fibrillation (AF) is a common and clinically heterogeneous arrythmia. Machine learning (ML) algorithms can define data-driven disease subtypes in an unbiased fashion, but whether the AF subgroups defined in this way align with underlying mechanisms, such as high polygenic liability to AF or inflammation, and associate with clinical outcomes is unclear.

Methods: We identified individuals with AF in a large biobank linked to electronic health records (EHR) and genome-wide genotyping.

Performance of risk prediction models for post-liver transplant patient and graft survival over time.

Given liver transplantation organ scarcity, selection of recipients and donors to maximize post-transplant benefit is paramount. Several scores predict post-transplant outcomes by isolating elements of donor and recipient risk, including the donor risk index, Balance of Risk, pre-allocation score to predict survival outcomes following liver transplantation/survival outcomes following liver transplantation (SOFT), improved donor-to-recipient allocation score for deceased donors only/improved donor-to-recipient allocation score for both deceased and living donors (ID2EAL-D/-DR), and survival benefit (SB) models. No studies have examined the performance of these models over time, which is critical in an ever-evolving transplant landscape.

Statins in Cirrhosis: Hope or Hype?

In recent years, studies have demonstrated the benefits of statins in a range of chronic diseases separate from cardiovascular outcomes. Early studies in the context of chronic liver disease have suggested favorable effects of statins leading to slowed fibrosis progression, reduced portal pressures, decreased rates of hepatic decompensation, and improved survival. This has increased interest in the potential role that statins may have in the management of chronic liver disease and cirrhosis, though many questions remain unanswered, including concerns regarding the safety of higher dose statins in patients with advanced decompensated cirrhosis.

The association between mental illness and all-cause mortality in patients with cirrhosis: a Veterans Affairs retrospective cohort study.

Background: Mental health diagnoses are common and known to impact key outcomes in patients with chronic illnesses including cirrhosis. However, the independent impact of psychiatric comorbidities on mortality in these patients and potential mitigating effects of outpatient mental health-related care has not been well characterized.

Methods: This was a retrospective cohort study of patients with cirrhosis in the Veterans Health Administration between 2008 and 2021.

Assessing working memory capacity through picture span and feature binding with visual-graphic symbols during a visual search task with typical children and adults.

This study investigated developmental memory capacity through picture span and feature binding. Participants included third grade students and college age adults with typical development. Picture span was used to assess working memory capacity when participants were asked to identify, locate, and sequence common visual-graphic symbols from experimental grid displays.

Therapist Financial Strain and Turnover: Interactions with System-Level Implementation of Evidence-Based Practices.

Therapist turnover is a major problem in community mental health. Financial strain, which is composed of cognitive, emotional, and behavioral responses to the experience of economic hardship, is an understudied antecedent of therapist turnover given the tumultuous financial environment in community mental health. We prospectively examined the relationship between therapist financial strain and turnover in 247 therapists in 28 community mental health agencies.

Effects of intrapulmonary percussive ventilation on airway mucus clearance: A bench model.

Aim: To determine the ability of intrapulmonary percussive ventilation (IPV) to promote airway clearance in spontaneously breathing patients and those on mechanical ventilation.

Methods: An artificial lung was used to simulate a spontaneously breathing patient (Group 1), and was then connected to a mechanical ventilator to simulate a patient on mechanical ventilation (Group 2). An 8.

Non-participants in policy efforts to promote evidence-based practices in a large behavioral health system.

Background: System-wide training initiatives to support and implement evidence-based practices (EBPs) in behavioral health systems have become increasingly widespread. Understanding more about organizations who do not participate in EBP training initiatives is a critical piece of the dissemination and implementation puzzle if we endeavor to increase access in community settings.

Methods: We conducted 30 1-h semi-structured interviews with leaders in non-participating agencies who did not formally participate in system-wide training initiatives to implement EBPs in the City of Philadelphia, with the goal to understand why they did not participate.

DPOAE component estimates and their relationship to hearing thresholds.

Distortion product otoacoustic emissions (DPOAEs) recorded in the ear canal are a composite or vector sum of two underlying components. The relationship between hearing thresholds and DPOAE-component level, rather than composite level, has been of recent interest. Two different signal-processing methods, inverse fast Fourier transform (IFFT) with time-windowing and low-pass filtering, were used to obtain estimates of the levels of the two components.

Effects of a suppressor tone on distortion product otoacoustic emissions fine structure: why a universal suppressor level is not a practical solution to obtaining single-generator DP-grams.

Objectives: The use of a suppressor tone has been proposed as the method of choice in obtaining single-generator distortion product (DP) grams, the speculation being that such DP grams will be more predictive of hearing thresholds. Current distortion product otoacoustic emissions (DPOAE) theory points to the ear canal DPOAE signal being a complex interaction between multiple components. The effectiveness of a suppressor tone is predicted to be dependent entirely on the relative levels of these components.

Sources and mechanisms of DPOAE generation: implications for the prediction of auditory sensitivity.

Otoacoustic emissions (OAEs) have become a commonly used clinical tool for assessing cochlear health status, in particular, the integrity of the cochlear amplifier or motor component of cochlear function. Predicting hearing thresholds from OAEs, however, remains a research challenge. Models and experimental data suggest that there are two mechanisms involved in the generation of OAEs.

Generation of DPOAEs in the guinea pig.

In humans, distortion product otoacoustic emissions (DPOAEs) at frequencies lower than the f(2) stimulus frequency are a composite of two separate sources, these two sources involving two distinctly different mechanisms for their production: non-linear distortion and linear coherent reflection [Talmadge et al., J. Acoust.

What drives mechanical amplification in the mammalian cochlea?

The recent report by Peter Dallos and colleagues of the gene and protein responsible for outer hair cell somatic motility (Zheng, Shen, He, Long, Madison, & Dallos, 2000), and the work of James Hudspeth and colleagues demonstrating that vestibular stereocilia are capable of providing power that may boost the vibration of structures within the inner ear (Martin & Hudspeth, 1999), presents the tantalizing possibility that we may not be far away from answering the question what drives mechanical amplification in the mammalian cochlea? This article reviews the evidence for and against each of somatic motility as the motor, and a motor in the hair cell bundle, producing cochlear mechanical amplification. We consider three models based on somatic motility as the motor and two based on a motor in the hair cell bundle. Available evidence supports a hair cell bundle motor in nonmammals but the upper frequency limit of mammalian hearing in general exceeds that of nonmammals, in many cases by an order of magnitude or more.