Inequalities in accelerated cognitive decline: Resolving observational window bias using nested non-linear regression.

Introduction: Limited observational windows lead to conflicting results in studies examining educational differences in Alzheimer's disease and related dementias (ADRD) risk, due to observational window bias relative to onset of accelerated cognitive decline. This study tested a novel model to address observational window bias and tested for the presence and sources of disparities in accelerated cognitive declines due to ADRD.

Methods: The sample examined 167,314 cognitive assessments from 32,441 Health and Retirement Study participants.

Incidence of Dementia Before Age 65 Years Among World Trade Center Attack Responders.

Importance: Reports suggest that the individuals who served in rescue operations following the terrorist attacks on the World Trade Center (WTC) have poorer brain health than expected.

Objective: To assess the incidence of dementia before age 65 years in a prospective study of WTC responders and to compare incidence among responders with severe exposures to debris vs responders not exposed to building debris or who wore personalized protective equipment (PPE).

Design, Setting, And Participants: This prospective cohort study was conducted from November 1, 2014, to January 1, 2023, in an academic medical monitoring program available to verified WTC responders residing on Long Island, New York.

No evidence for chunking in spatial memory of route experience.

Spatial memory is important for supporting the successful completion of everyday activities and is a particularly vulnerable domain in late life. Grouping items together in memory, or chunking, can improve spatial memory performance. In memory for desktop scale spaces and well-learned large-scale environments, error patterns suggest that information is chunked in memory.

Predicting internalizing symptoms with machine learning: identifying individuals that need care.

The current project aims to identify individuals in urgent need of mental health care, using a machine learning algorithm (random forest). Comparison/contrast with conventional regression analyses is discussed. A total of 2,409 participants were recruited from an anonymous university, including undergraduate and graduate students, faculty, and staff.

Loss of mental health support among college students during the COVID-19 pandemic.

: The COVID-19 pandemic has simultaneously exacerbated mental health concerns among college students and made it more challenging for many students to access mental health support. However, little is known about the extent of mental health support loss among college students, or which students have lost support. 415 undergraduate students who reported receiving mental health support prior to the pandemic participated.

Personal and collective mental time travel across the adult lifespan during COVID-19.

Older adults exhibit an , with more positivity for memories than young adults. Theoretical explanations attribute this phenomenon to greater emphasis on emotion regulation and well-being due to shortened time horizons. Adults, across the lifespan, also exhibit a (more negativity about their country than their personal past and future) and a (more positivity for future projections than for memories).

COVID-19 experiences and psychopathology symptoms in college students at the onset of the pandemic.

The present study examined what specific aspects of the COVID-19 pandemic contributed to psychopathology symptoms among college students during the initial stages of the pandemic. One thousand and eighty-nine college students ( = 20.73, = 2.

Explainable automated evaluation of the clock drawing task for memory impairment screening.

Introduction: The clock drawing task (CDT) is frequently used to aid in detecting cognitive impairment, but current scoring techniques are time-consuming and miss relevant features, justifying the creation of an automated quantitative scoring approach.

Methods: We used computer vision methods to analyze the stored scanned images ( = 7,109), and an intelligent system was created to examine these files in a study of aging World Trade Center responders. Outcomes were CDT, Montreal Cognitive Assessment (MoCA) score, and incidence of mild cognitive impairment (MCI).

Just write it down: Similarity in the benefit from cognitive offloading in young and older adults.

Past research conducted primarily in young adults has demonstrated the utility of cognitive offloading for benefitting performance of memory-based tasks, particularly at high memory loads. At the same time, older adults show declines in a variety of memory abilities, including subtle changes in short-term memory, suggesting that cognitive offloading could also benefit performance of memory-based tasks in this group. To this end, 94 participants (62 young adults, 32 older adults) were tested on a retrospective audiovisual short-term memory task in two blocked conditions.

Gender and Racial/Ethnic Disparities in Undergraduate and Graduate Students' Mental Health and Treatment Use Amid the COVID-19 Pandemic.

The COVID-19 pandemic has negatively impacted numerous people?s mental health and created new barriers to services. To address the unknown effects of the pandemic on accessibility and equality issues in mental health care, this study aimed to investigate gender and racial/ethnic disparities in mental health and treatment use in undergraduate and graduate students amid the COVID-19 pandemic. The study was conducted based on a largescale online survey (N = 1,415) administered during the weeks following a pandemic-related university-wide campus closure in March 2020.

Take a load off: examining partial and complete cognitive offloading of medication information.

Although cognitive offloading, or the use of physical action to reduce internal cognitive demands, is a commonly used strategy in everyday life, relatively little is known about the conditions that encourage offloading and the memorial consequences of different offloading strategies for performance. Much of the extant work in this domain has focused on laboratory-based tasks consisting of word lists, letter strings, or numerical stimuli and thus makes little contact with real-world scenarios under which engaging in cognitive offloading might be likely. Accordingly, the current work examines offloading choice behavior and potential benefits afforded by offloading health-related information.

Adult age differences in subjective context retrieval in dual-list free recall.

Age-related episodic memory deficits imply that older and younger adults differentially retrieve and monitor contextual features that indicate the source of studied information. Such differences have been shown in subjective reports during recognition and cued recall as well as process estimates derived from computational models of free recall organisation. The present study extends the subject report method to free recall to characterise age differences in context retrieval and monitoring, and to test assumptions from a context-based computational model.

Virtual navigation in healthy aging: Activation during learning and deactivation during retrieval predicts successful memory for spatial locations.

Spatial navigation and spatial memory are two important skills for independent living, and are known to be compromised with age. Here, we investigate the neural correlates of successful spatial memory in healthy older adults in order to learn more about the neural underpinnings of maintenance of navigation skill into old age. Healthy older adults watched a video shot by a person navigating a route and were asked to remember objects along the route and then attempted to remember object locations by virtually pointing to the location of hidden objects from several locations along the route.

College student interest in teletherapy and self-guided mental health supports during the COVID-19 pandemic.

The COVID-19 pandemic has worsened college students' mental health while simultaneously creating new barriers to traditional in-person care. Teletherapy and online self-guided mental health supports are two potential avenues for addressing unmet mental health needs when face-to-face services are less accessible, but little is known about factors that shape interest in these supports. 1,224 U.

Episodic Memory Performance Modifies the Strength of the Age-Brain Structure Relationship.

The bivariate relationships between brain structure, age, and episodic memory performance are well understood. Advancing age and poorer episodic memory performance are each associated with smaller brain volumes and lower cortical thickness measures, respectively. Advancing age is also known to be associated with poorer episodic memory task scores on average.

A deep learning approach for monitoring parietal-dominant Alzheimer's disease in World Trade Center responders at midlife.

Little is known about the characteristics and causes of early-onset cognitive impairment. Responders to the 2001 New York World Trade Center disaster represent an ageing population that was recently shown to have an excess prevalence of cognitive impairment. Neuroimaging and molecular data demonstrate that a subgroup of affected responders may have a unique form of parietal-dominant Alzheimer's Disease.

Performance on the processing portion of complex working memory span tasks is related to working memory capacity estimates.

Individual differences in working memory capacity (WMC) have long been known to relate to performance in domains outside of WM, including attentional control, long-term memory, problem-solving, and fluid intelligence to name a few. Complex span WM tasks, composed of a processing component and a storage component, are often used to index WMC in these types of investigations. Capacity estimates are derived from performance on the storage component only, while processing performance is often largely ignored.

Pattern Recognition to Objectively Differentiate the Etiology of Cognitive Decline: Analysis of the Impact of Stroke and Alzheimer's Disease.

Background: Undetected Alzheimer's disease (AD) and stroke neuropathology is believed to account for a large proportion of decline in cognitive performance that is attributed to normal aging. This study examined the amount of variance in age-related cognitive change that is accounted for by AD and stroke using a novel pattern recognition protocol.

Method: Secondary analyses of data collected for the Health and Retirement Study (N = 17,579) were used to objectively characterize patterns of cognitive decline associated with AD and stroke.

Offloading items from memory: individual differences in cognitive offloading in a short-term memory task.

Cognitive offloading refers to the act of reducing the mental processing requirements of a task through physical actions like writing down information or storing information on a cell phone or computer. Offloading can lead to improved performance on ongoing tasks with high cognitive demand, such as tasks where multiple pieces of information must be simultaneously maintained. However, less is known about why some individuals choose to engage in offloading and under what conditions they might choose to do so.

Age differences in spatial memory for mediated environments.

Compared with younger adults, older adults have more difficulty with navigation and spatial memory in both familiar and unfamiliar domains. However, the cognitive mechanisms underlying these effects have been little explored. We examined three potential factors: (a) use of and coordination across spatial reference frames, (b) nonspatial cognitive abilities, and (c) the ability to segment a route into effective chunks.

Event perception: Translations and applications.

Event segmentation is the parsing of ongoing activity into meaningful events. Segmenting in a normative fashion-identifying event boundaries similar to others' boundaries-is associated with better memory for and better performance of naturalistic actions. Given this, a reasonable hypothesis is that interventions that improve memory and attention for everyday events could lead to improvement in domains that are important for independent living, particularly in older populations.

Constructing Experience: Event Models from Perception to Action.

Mental representations of everyday experience are rich, structured, and multimodal. In this article we consider the adaptive pressures that led to human construction of such representations, arguing that structured event representations enable cognitive systems to more effectively predict the trajectory of naturalistic everyday activity. We propose an account of how cortical systems and the hippocampus (HPC) interact to construct, maintain, and update event representations.

Adult age differences in production and monitoring in dual-list free recall.

The present experiment examined adult age differences in the production and monitoring of responses in dual-list free recall. Younger and older adults studied 2 lists of unrelated words and were instructed to recall from List 1, List 2, or List 1 and List 2. An externalized free recall procedure required participants to: (a) report all responses that came to mind while recalling from specific lists, (b) classify responses as correct or incorrect, and (c) provide confidence judgments for their accuracy classifications.