Publications by authors named "Lauren R Agnew"
Article Synopsis
- The text discusses a comprehensive strategy that integrates multiple areas of chemistry—synthetic, physical, and analytical—along with high-throughput experimentation and process engineering, aimed at developing a large-scale Suzuki-Miyaura process.
- It emphasizes the importance of setting clear criteria and targets to guide the research and optimization of the process.
- The document details the decision-making process and the methods used to enhance the efficiency and effectiveness of large-scale pharmaceutical manufacturing.
A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent "templating" approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.
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